Neuregulin-1 Type I: A Hidden Power Within Schwann Cells for Triggering Peripheral Nerve Remyelination

被引：17

作者：

Krishnan, Anand ^{[1
]}

机构：

[1] Univ Calgary, Hotchkiss Brain Inst, Dept Clin Neurosci, Calgary, AB T2N 4N1, Canada

来源：

SCIENCE SIGNALING | 2013年 / 6卷 / 270期

关键词：

MYELINATION; SIGNAL;

D O I：

10.1126/scisignal.2003945

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Physiological interactions and reciprocal signaling between axons and Schwann cells play critical roles in nerve development and survival. Axonally derived neuregulin-1 (NRG-1) type III is an essential modulator of Schwann cells during development, nerve repair, and remyelination. A recent report demonstrates an unexpected regulatory role for Schwann cell-derived NRG-1 type I in Schwann cell plasticity and remyelination after peripheral nerve injury. Specifically expressed in Schwann cells at critical time points after nerve injury, this isoform of NRG-1 emerges as a driving force for regeneration and remyelination programs.

引用

页数：3

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