Neuregulin-1 Type I: A Hidden Power Within Schwann Cells for Triggering Peripheral Nerve Remyelination

被引：17
|
作者：
Krishnan, Anand [1 ]
机构：
[1] Univ Calgary, Hotchkiss Brain Inst, Dept Clin Neurosci, Calgary, AB T2N 4N1, Canada
来源：
SCIENCE SIGNALING | 2013年 / 6卷 / 270期
关键词：
MYELINATION; SIGNAL;
D O I：
10.1126/scisignal.2003945
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Physiological interactions and reciprocal signaling between axons and Schwann cells play critical roles in nerve development and survival. Axonally derived neuregulin-1 (NRG-1) type III is an essential modulator of Schwann cells during development, nerve repair, and remyelination. A recent report demonstrates an unexpected regulatory role for Schwann cell-derived NRG-1 type I in Schwann cell plasticity and remyelination after peripheral nerve injury. Specifically expressed in Schwann cells at critical time points after nerve injury, this isoform of NRG-1 emerges as a driving force for regeneration and remyelination programs.
引用
收藏
页数：3
相关论文
共 50 条
  • [21] Expression pattern of neuregulin-1 type Ⅲ during the development of the peripheral nervous system
    Liang-liang Huang
    Zhong-yang Liu
    Jing-hui Huang
    Zhuo-jing Luo
    Neural Regeneration Research, 2015, 10 (01) : 65 - 70
  • [22] Expression pattern of neuregulin-1 type III during the development of the peripheral nervous system
    Huang, Liang-liang
    Liu, Zhong-yang
    Huang, Jing-hui
    Luo, Zhuo-jing
    NEURAL REGENERATION RESEARCH, 2015, 10 (01) : 65 - 70
  • [23] Neuregulin 1 Role in Schwann Cell Regulation and Potential Applications to Promote Peripheral Nerve Regeneration
    Gambarotta, Giovanna
    Fregnan, Federica
    Gnavi, Sara
    Perroteau, Isabelle
    TISSUE ENGINEERING OF THE PERIPHERAL NERVE: STEM CELLS AND REGENERATION PROMOTING FACTORS, 2013, 108 : 223 - 256
  • [24] Neuregulin-1 growth factors and their ERBB receptors promote mitogenesis in human malignant peripheral nerve sheath tumor cells.
    Carroll, SL
    Stonecypher, MS
    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2004, 63 (05): : 517 - 517
  • [25] DIFFERENTIAL NEUREGULIN-1 TYPE III LOCALIZATION: DISTINCT FUNCTIONS IN CENTRAL AND PERIPHERAL NERVOUS SYSTEM
    DeVries, G. H.
    Becker-Catania, S.
    Bare, D. J.
    JOURNAL OF NEUROCHEMISTRY, 2009, 108 : 120 - 120
  • [26] Migrating Schwann cells direct axon regeneration within the peripheral nerve bridge
    Min, Qing
    Parkinson, David B.
    Dun, Xin-Peng
    GLIA, 2021, 69 (02) : 235 - 254
  • [27] NEUREGULIN-1 TYPE I ENHANCES FUNCTIONAL RECOVERY AFTER ACUTE PERIPHERAL NERVE INJURY AND RESCUES AXONAL LOSS IN A MOUSE MODEL FOR CHARCOT MARIE TOOTH DISEASE 1A
    Fledrich, R.
    Stassart, R. M.
    Haag, L. M.
    Veselcic, P.
    Czesnik, D.
    Nave, K. -A.
    Sereda, M. W.
    GLIA, 2013, 61 : S198 - S198
  • [28] Schwann-like mesenchymal stem cells within vein graft facilitate facial nerve regeneration and remyelination
    Wang, Xuemei
    Luo, En
    Li, Yunfeng
    Hu, Jing
    BRAIN RESEARCH, 2011, 1383 : 71 - 80
  • [29] Role of neuregulin-1β in dexamethasone-enhanced surfactant synthesis in fetal type II cells
    King, George
    Maker, Garth L.
    Berryman, David
    Trengove, Robert D.
    Cake, Max H.
    FEBS LETTERS, 2014, 588 (06) : 975 - 980
  • [30] The effect of neuregulin-1 on the survival of Schwann-like cells via the PI3K/Akt/Bad pathway
    Yang, Xizhong
    Ji, Cuijie
    Song, Qijing
    Xie, Zongkai
    Yu, Guoyi
    Li, Shaoke
    Cui, Congxian
    Shen, Ruowu
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2019, 12 (12): : 13635 - 13642
12345