Dual Role of (NH4)2CO3 Enables Defluorinative Synthesis of β-Fluoroalkylated Aminovinyl Ketones

被引：12

作者：

Chen, Yu-Lan ^{[1
]}

Han, Wei ^{[1
]}

Feng, Man-Hang ^{[1
]}

Zhang, Peng-Yuan ^{[1
]}

Ma, Mengtao ^{[2
]}

Shen, Zhi-Liang ^{[1
]}

Chu, Xue-Qiang ^{[1
]}

机构：

[1] Nanjing Tech Univ, Tech Inst Fluorochem TIF, Inst Adv Synth, Sch Chem & Mol Engn, Nanjing 211816, Peoples R China

[2] Nanjing Forestry Univ, Coll Sci, Dept Chem & Mat Sci, Nanjing 210037, Peoples R China

来源：

ORGANIC LETTERS | 2022年 / 24卷 / 49期

基金：

中国国家自然科学基金;

关键词：

ONE-POT SYNTHESIS; DERIVATIVES; CHEMISTRY;

D O I：

10.1021/acs.orglett.2c03745

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A modular multicomponent reaction of readily available fluoroalkyl alkenes, amidines, ammonium carbonate, and water was developed for the facile construction of beta-fluoroalkylated aminovinyl ketones, which provided chemists a novel access to value-added organofluorine compounds. The reaction proceeded regio-/stereoselectively under mild conditions and exhibited good functional group tolerance. Cheap, stable, and low-toxic inorganic salt (NH4)2CO3 was first found to act as both a nitrogen source and a carbonyl equivalent in the multi-bond-forming process.

引用

页码：9086 / 9091

页数：6

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