The VPAC2 receptor is essential for circadian function in the mouse suprachiasmatic nuclei

被引：452
作者：
Harmar, AJ
Marston, HM
Shen, SB
Spratt, C
West, KM
Sheward, WJ
Morrison, CF
Dorin, JR
Piggins, HD
Reubi, JC
Kelly, JS
Maywood, ES
Hastings, MH
机构：
[1] Univ Edinburgh, Dept Neurosci, Edinburgh EH8 9JZ, Midlothian, Scotland
[2] Univ Edinburgh, Fujisawa Inst Neurosci, Edinburgh EH8 9JZ, Midlothian, Scotland
[3] Western Gen Hosp, MRC, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland
[4] Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England
[5] Univ Bern, Inst Pathol, CH-3010 Bern, Switzerland
[6] MRC, Mol Biol Lab, Cambridge CB2 2QH, England
来源：
CELL | 2002年 / 109卷 / 04期
基金：
英国医学研究理事会; 英国惠康基金;
关键词：
D O I：
10.1016/S0092-8674(02)00736-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The neuropeptides pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are implicated in the photic entrainment of circadian rhythms in the suprachiasmatic nuclei (SON). We now report that mice carrying a null mutation of the VPAC(2) receptor for VIP and PACAP(Vipr2(-/-)) are incapable of sustaining normal circadian rhythms of rest/activity behavior. These mice also fail to exhibit circadian expression of the core clock genes mPer1, mPer2, and mCry1 and the clock-controlled gene arginine vasopressin (AVP) in the SON. Moreover, the mutants fail to show acute induction of mPer1 and mPer2 by nocturnal illumination. This study highlights the role of intercellular neuropeptidergic signaling in maintenance of circadian function within the SCN.
引用
收藏
页码：497 / 508
页数：12
相关论文
共 50 条
[21]  
Hastings M H, 1999, J Neurosci, V19, pRC11
[22]   Circadian clockwork: two loops are better than one [J].
Hastings, MH .
NATURE REVIEWS NEUROSCIENCE, 2000, 1 (02) :143-146
[23]   A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock [J].
Jin, XW ;
Shearman, LP ;
Weaver, DR ;
Zylka, MJ ;
De Vries, GJ ;
Reppert, SM .
CELL, 1999, 96 (01) :57-68
[24]   RETINOHYPOTHALAMIC PROJECTIONS IN THE HAMSTER AND RAT DEMONSTRATED USING CHOLERA-TOXIN [J].
JOHNSON, RF ;
MORIN, LP ;
MOORE, RY .
BRAIN RESEARCH, 1988, 462 (02) :301-312
[25]   Nonphotic entrainment of activity and temperature rhythms in anophthalmic mice [J].
Laemle, LK ;
Ottenweller, JE .
PHYSIOLOGY & BEHAVIOR, 1999, 66 (03) :461-471
[26]   Posttranslational mechanisms regulate the mammalian circadian clock [J].
Lee, C ;
Etchegaray, JP ;
Cagampang, FRA ;
Loudon, ASI ;
Reppert, SM .
CELL, 2001, 107 (07) :855-867
[27]   Chromosomal localization in mouse and human of the vasoactive intestinal peptide receptor type 2 gene: A possible contributor to the holoprosencephaly 3 phenotype [J].
Mackay, M ;
Fantes, J ;
Scherer, S ;
Boyle, S ;
West, K ;
Tsui, LC ;
Belloni, E ;
Lutz, E ;
VanHeyningen, V ;
Harmar, AJ .
GENOMICS, 1996, 37 (03) :345-353
[28]   Circadian activity rhythm in methamphetamine-treated Clock mutant mice [J].
Masubuchi, S ;
Honma, S ;
Abe, H ;
Nakamura, W ;
Honma, K .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2001, 14 (07) :1177-1180
[29]   Photic induction of mPer1 and mPer2 in Cry-deficient mice lacking a biological clock [J].
Okamura, H ;
Miyake, S ;
Sumi, Y ;
Yamaguchi, S ;
Yasui, A ;
Muijtjens, M ;
Hoeijmakers, JHJ ;
van der Horst, GTJ .
SCIENCE, 1999, 286 (5449) :2531-2534
[30]  
PIGGINS HD, 1995, J NEUROSCI, V15, P5612
12345