New coeliac disease treatments and their complications

被引：13

作者：

Vaquero, Luis ^{[1
]}

Rodriguez-Martin, Laura ^{[1
]}

Leon, Francisco ^{[2
]}

Jorquera, Francisco ^{[1
,3
]}

Vivas, Santiago ^{[1
,3
]}

机构：

[1] Complejo Asistencial Univ Leon, Serv Aparato Digest, Leon, Spain

[2] Celimmune, Bethesda, MD USA

[3] Univ Leon, Inst Biomed IBIOMED, Leon, Spain

来源：

GASTROENTEROLOGIA Y HEPATOLOGIA | 2018年 / 41卷 / 03期

关键词：

Coeliac disease; Gluten-free diet; Gluten-sensitive enteropathy; T-CELL LYMPHOMA; GLUTEN-FREE DIET; INTESTINAL BARRIER FUNCTION; NF-KAPPA-B; ALPHA-GLIADIN; 1ST-DEGREE RELATIVES; LARAZOTIDE ACETATE; CROHNS-DISEASE; TISSUE TRANSGLUTAMINASE; THERAPEUTIC STRATEGIES;

D O I：

10.1016/j.gastrohep.2017.12.002

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The only accepted treatment for coeliac disease is strict adherence to a gluten-free diet. This type of diet may give rise to reduced patient quality of life with economic and social repercussions. For this reason, dietary transgressions are common and may elicit intestinal damage. Several treatments aimed at different pathogenic targets of coeliac disease have been developed in recent years: modification of gluten to produce non-immunogenic gluten, endoluminal therapies to degrade gluten in the intestinal lumen, increased gluten tolerance, modulation of intestinal permeability and regulation of the adaptive immune response. This review evaluates these coeliac disease treatment lines that are being researched and the treatments that aim to control disease complications like refractory coeliac disease. (C) 2018 Elsevier Espana, S.L.U. All rights reserved.

引用

页码：191 / 204

页数：14

共 117 条

[1] Tolerable amount of gluten for people with coeliac disease
Akobeng, A. K.
Thomas, A. G.
[J]. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2008, 27 (11) : 1044 - 1052
[2] Survival in refractory coeliac disease and enteropathyassociated T-cell lymphoma: retrospective evaluation of single-centre experience
Al-Toma, A.
Verbeek, W. H. M.
Hadithi, M.
von Blomberg, B. M. E.
Mulder, C. J. J.
[J]. GUT, 2007, 56 (10) : 1373 - 1378
[3] Disappointing outcome of autologous stem cell transplantation for enteropathy-associated T-cell lymphoma
Al-Toma, A.
Verbeek, W. H. M.
Visser, O. J.
Kuijpers, K. C.
Oudejans, J. J.
Kluin-Nelemans, H. C.
Mulder, C. J. J.
Huijgens, P. C.
[J]. DIGESTIVE AND LIVER DISEASE, 2007, 39 (07) : 634 - 641
[4] Cladribine therapy in refractory celiac disease with aberrant T cells
Al-Toma, Abdulbaqi
Goerres, Marije S.
Meijer, Jos W. R.
Von Blomberg, B. Mary E.
Wahab, Peter J.
Kerckhaert, Jo A. M.
Mulder, Chris J. J.
[J]. CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2006, 4 (11) : 1322 - 1327
[5] In vivo antigen challenge in celiac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T-cell epitope
Anderson, RP
Degano, P
Godkin, AJ
Jewell, DP
Hill, AVS
[J]. NATURE MEDICINE, 2000, 6 (03) : 337 - 342
[6] Celiac lesion T cells recognize epitopes that cluster in regions of gliadins rich in proline residues
Arentz-Hansen, H
McAdam, SN
Molberg, O
Fleckenstein, B
Lundin, KEA
Jorgensen, TJD
Jung, G
Roepstorff, P
Sollid, LM
[J]. GASTROENTEROLOGY, 2002, 123 (03) : 803 - 809
[7] Aziz I, 2011, J GASTROINTEST LIVER, V20, P27
[8] Bager P, 2010, J ALLERGY CLIN IMMUN, V125, P123
[9] Gluten-induced nitric oxide and pro-inflammatory cytokine release by cultured coeliac small intestinal biopsies
Beckett, CG
Dell'Olio, D
Shidrawi, RG
Rosen-Bronson, S
Ciclitira, PJ
[J]. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 1999, 11 (05) : 529 - 535
[10] ALPHA-4-BETA-7-INTEGRIN MEDIATES LYMPHOCYTE BINDING TO THE MUCOSAL VASCULAR ADDRESSIN MADCAM-1
BERLIN, C
BERG, EL
BRISKIN, MJ
ANDREW, DP
KILSHAW, PJ
HOLZMANN, B
WEISSMAN, IL
HAMANN, A
BUTCHER, EC
[J]. CELL, 1993, 74 (01) : 185 - 195

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