No acute suppression of cerebrospinal fluid corticotropin-releasing hormone in man by cortisol administration

被引：1

作者：

Kellner, Michael ^{[1
]}

Salzwedel, Cornelie ^{[2
]}

Wortmann, Viola ^{[1
]}

Urbanowicz, Tatiana ^{[1
]}

Boelmans, Kai ^{[1
]}

Yassouridis, Alexander ^{[3
]}

Stalla, Guenter K. ^{[3
]}

Wiedemann, Klaus ^{[1
]}

机构：

[1] Univ Hosp Hamburg Eppendorf, Dept Psychiat & Psychotherapy, D-20246 Hamburg, Germany

[2] Univ Hosp Hamburg Eppendorf, Dept Anesthesiol, D-20246 Hamburg, Germany

[3] Max Planck Inst Psychiat, D-80804 Munich, Germany

来源：

PSYCHIATRY RESEARCH | 2013年 / 210卷 / 02期

关键词：

Corticotropin-releasing hormone (CRH); Cortisol; Cerebrospinal fluid (CSF); DIFFERENTIAL REGULATION; MESSENGER-RNA; FACTOR CRF; HEALTHY; RHYTHM;

D O I：

10.1016/j.psychres.2013.07.003

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Corticotropin-releasing hormone (CRH) in cerebrospinal fluid (CSF) is regarded as index of brain endocrine and behavioral functioning. We investigated the acute effects of intravenous cortisol (100 mg) vs. placebo on serial CSF CRH in ten healthy men. CSF CRH concentrations were not significantly suppressed by cortisol within 3 h. The origin and regulation of CSF CRH need further research. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：662 / 664

页数：3

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