Pterocarpans and triterpenoids from Gueldenstaedtia verna

被引：8

作者：

Yin, Chengle ^{[1
]}

Zhou, Jinge ^{[2
]}

Wu, Yiqing ^{[1
]}

Cao, Yue ^{[1
]}

Wu, Tao ^{[2
]}

Zhang, Shoude ^{[3
]}

Li, Honglin ^{[3
]}

Cheng, Zhihong ^{[1
]}

机构：

[1] Fudan Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 201203, Peoples R China

[2] Shanghai Univ Tradit Chinese Med, Key Lab Standardizat Chinese Med, Minist Educ, Shanghai Key Lab Compound Chinese Med,Inst Chines, Shanghai 201203, Peoples R China

[3] E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China

来源：

FITOTERAPIA | 2015年 / 106卷

基金：

中国国家自然科学基金;

关键词：

Gueldenstaedtia verna; Leguminosae; Pterocarpans; Triterpenoids; Cytotoxic activity; Inhibition of NO production; INHIBITORY-ACTIVITY; MASS-SPECTROMETRY; VIOLA-YEDOENSIS; FLAVONOIDS; CONSTITUENTS; GLYCOSIDES; SAPONINS; RIBOFURANOSIDE; ISOFLAVONOIDS; ROOTS;

D O I：

10.1016/j.fitote.2015.07.021

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new pterocarpan glycosides (1-2), five new triterpenoids (3-7), and 13 known analogues (14-20) were isolated from the whole plants of Gueldenstaedtia verna. These new compounds (1-7) were elucidated by extensive spectroscopic techniques including 1D (H-1 and C-13) and 2D NMR experiments (COSY, HSQC, HMBC and NOESY), HR-ESI-MS and chemical methods. The absolute configuration of 1 was established by the optical rotation, the comparison of experimental and calculated electronic circular dichroism (ECD) spectra and an X-ray diffraction analysis. All the isolates were evaluated for their cytotoxicities against four human cancer cell lines and inhibitory activities on LPS-induced NO production in RAW264.7 cells. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：46 / 54

页数：9

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