A Case of Fatal Strongyloidiasis in a Patient with Chronic Lymphocytic Leukemia and Molecular Characterization of the Isolate

被引:19
作者
Kia, Eshrat Beigom [1 ]
Rahimi, Hamid Reza [2 ]
Mirhendi, Hossein [1 ]
Nilforoushan, Mohammad Reza [1 ]
Talebi, Ardeshir [2 ]
Zahabiun, Farzaneh [1 ]
Kazemzadeh, Hamid [2 ]
Meamar, Ahmad Reza [3 ]
机构
[1] Med Sci Univ Tehran, Sch Publ Hlth, Tehran, Iran
[2] Isfahan Univ Med Sci, Al Zahra Med Ctr, Esfahan, Iran
[3] Iran Univ Med Sci, Sch Med, Tehran, Iran
关键词
Strongyloides stercoralis; hyperinfection; chronic lymphocytic leukemia; ITS1; ribosomal DNA;
D O I
10.3347/kjp.2008.46.4.261
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Strongyloides stercoralis is a human intestinal parasite which may lead to complicated strongyloidiasis in immunocompromised. Here, a case of complicated strongyloidiasis in a patient with chronic lymphocytic leukemia is reported. Presence of numerous S. stercoralis larvae in feces and sputum confirmed the diagnosis of hyperinfection syndrome in this patient. Following recovery of filariform larvae from agar plate culture of the stool, the isolate was characterized for the ITS1 region of ribosomal DNA gene by nested-PCR and sequencing. Albendazole therapy did not have cure effects; and just at the beginning of taking ivermectin, the patient died. The most important clue to prevent such fatal consequences is early diagnosis and proper treatment.
引用
收藏
页码:261 / 263
页数:3
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