Human H7N9 Influenza A Viruses Replicate in Swine Respiratory Tissue Explants

被引：14

作者：

Jones, J. C. ^{[1
]}

Baranovich, T. ^{[1
]}

Zaraket, H. ^{[1
]}

Guan, Y. ^{[2
,3
,4
]}

Shu, Y. ^{[5
]}

Webby, R. J.

Webster, R. G. ^{[1
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 USA

[2] Shantou Univ, Joint Influenza Res Ctr Shantou Univ Med Coll SUM, Shantou, Peoples R China

[3] Shenzhen Third Peoples Hosp, State Key Lab Emerging Infect Dis HKU Shenzhen Br, Shenzhen, Peoples R China

[4] Univ Hong Kong, Sch Publ Hlth, Influenza Res Ctr, State Key Lab Emerging Infect Dis, Hong Kong, Hong Kong, Peoples R China

[5] Chinese Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent, Key Lab Med Virol Natl Hlth & Family Planning Com, Beijing, Peoples R China

来源：

JOURNAL OF VIROLOGY | 2013年 / 87卷 / 22期

基金：

美国国家卫生研究院;

关键词：

PANDEMIC INFLUENZA; HUMAN INFECTION; DIVERSITY; EMERGENCE; POULTRY; ORIGIN; CHINA; PIGS;

D O I：

10.1128/JVI.02499-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Recently, novel H7N9 influenza viruses have caused an unprecedented outbreak in humans. Pigs are an important intermediate host for influenza; thus, we assessed the replication ability of three human H7N9 viruses (A/Anhui/1/2013, A/Shanghai/1/2013, A/Shanghai/2/2013) in swine tissue explants. All viruses tested replicated efficiently in explants from tracheas and bronchi, with limited replication in alveolar cells. Swine respiratory tissue explants can serve as an efficient model for screening replication potential of newly emerging H7N9 viruses.

引用

页码：12496 / 12498

页数：3

共 18 条

[1]

[Anonymous], 2013, HUM INF AV INFL H7N9

[2] Diversity of influenza viruses in swine and the emergence of a novel human pandemic influenza A (H1N1) [J].

Brockwell-Staats, Christy ;

Webster, Robert G. ;

Webby, Richard J. .

INFLUENZA AND OTHER RESPIRATORY VIRUSES, 2009, 3 (05) :207-213

[3] Tissue Tropism of Swine Influenza Viruses and Reassortants in Ex Vivo Cultures of the Human Respiratory Tract and Conjunctiva [J].

Chan, Renee W. Y. ;

Kang, Sara S. R. ;

Yen, Hui-Ling ;

Li, Alan C. L. ;

Tang, Lynsia L. S. ;

Yu, Wendy C. L. ;

Yuen, Kit M. ;

Chan, Icarus W. W. ;

Wong, Diana D. Y. ;

Lai, Wico W. ;

Kwong, Dora L. W. ;

Sihoe, Alan D. L. ;

Poon, Leo L. M. ;

Guan, Yi ;

Nicholls, John M. ;

Peiris, J. S. Malik ;

Chan, Michael C. W. .

JOURNAL OF VIROLOGY, 2011, 85 (22) :11581-11587

[4] The first case of H7N9 influenza in Taiwan [J].

Chang, Sui-Yuan ;

Lin, Pi-Han ;

Tsai, Jen-Chih ;

Hung, Chien-Ching ;

Chang, Shan-Chwen .

LANCET, 2013, 381 (9878) :1621-1621

[5] Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome [J].

Chen, Yu ;

Liang, Weifeng ;

Yang, Shigui ;

Wu, Nanping ;

Gao, Hainv ;

Sheng, Jifang ;

Yao, Hangping ;

Wo, Jianer ;

Fang, Qiang ;

Cui, Dawei ;

Li, Yongcheng ;

Yao, Xing ;

Zhang, Yuntao ;

Wu, Haibo ;

Zheng, Shufa ;

Diao, Hongyan ;

Xia, Shichang ;

Zhang, Yanjun ;

Chan, Kwok-Hung ;

Tsoi, Hoi-Wah ;

Teng, Jade Lee-Lee ;

Song, Wenjun ;

Wang, Pui ;

Lau, Siu-Ying ;

Zheng, Min ;

Chan, Jasper Fuk-Woo ;

To, Kelvin Kai-Wang ;

Chen, Honglin ;

Li, Lanjuan ;

Yuen, Kwok-Yung .

LANCET, 2013, 381 (9881) :1916-1925

[6] Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus [J].

Gao, Rongbao ;

Cao, Bin ;

Hu, Yunwen ;

Feng, Zijian ;

Wang, Dayan ;

Hu, Wanfu ;

Chen, Jian ;

Jie, Zhijun ;

Qiu, Haibo ;

Xu, Ke ;

Xu, Xuewei ;

Lu, Hongzhou ;

Zhu, Wenfei ;

Gao, Zhancheng ;

Xiang, Nijuan ;

Shen, Yinzhong ;

He, Zebao ;

Gu, Yong ;

Zhang, Zhiyong ;

Yang, Yi ;

Zhao, Xiang ;

Zhou, Lei ;

Li, Xiaodan ;

Zou, Shumei ;

Zhang, Ye ;

Li, Xiyan ;

Yang, Lei ;

Guo, Junfeng ;

Dong, Jie ;

Li, Qun ;

Dong, Libo ;

Zhu, Yun ;

Bai, Tian ;

Wang, Shiwen ;

Hao, Pei ;

Yang, Weizhong ;

Zhang, Yanping ;

Han, Jun ;

Yu, Hongjie ;

Li, Dexin ;

Gao, George F. ;

Wu, Guizhen ;

Wang, Yu ;

Yuan, Zhenghong ;

Shu, Yuelong .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 368 (20) :1888-1897

[7]

Jernigan D, 2013, MMWR-MORBID MORTAL W, V62, P366

[8]

Kageyama T, 2013, EUROSURVEILLANCE, V18, P7

[9] Pigs, Poultry, and Pandemic Influenza: How Zoonotic Pathogens Threaten Human Health [J].

Kuiken, Thijs ;

Fouchier, Ron ;

Rimmelzwaan, Guus ;

van den Brand, Judith ;

van Riel, Debby ;

Osterhaus, Albert .

HOT TOPICS IN INFECTION AND IMMUNITY IN CHILDREN VIII, 2011, 719 :59-66

[10] Origin and diversity of novel avian influenza A H7N9 viruses causing human infection: phylogenetic, structural, and coalescent analyses [J].

Liu, Di ;

Shi, Weifeng ;

Shi, Yi ;

Wang, Dayan ;

Xiao, Haixia ;

Li, Wei ;

Bi, Yuhai ;

Wu, Ying ;

Li, Xianbin ;

Yan, Jinghua ;

Liu, Wenjun ;

Zhao, Guoping ;

Yang, Weizhong ;

Wang, Yu ;

Ma, Juncai ;

Shu, Yuelong ;

Lei, Fumin ;

Gao, George F. .

LANCET, 2013, 381 (9881) :1926-1932

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