New insight into air flow distribution in alveoli based on air- and saline-filled lungs

被引:7
作者
Dong, Jun [1 ]
Yang, Yue [1 ]
Zhu, Yonggang [1 ]
机构
[1] Harbin Inst Technol, Sch Mech Engn & Automat, Shenzhen 518055, Guangdong, Peoples R China
基金
中国国家自然科学基金;
关键词
Alveoli; Expansion ratio; Flow distribution; Alveolar to ductal flow ratio; Surface tension; AEROSOL DEPOSITION; PULMONARY ACINUS; TRANSPORT; AIRWAYS; MODEL; DISPERSION; DELIVERY; HEALTHY; GAS;
D O I
10.1007/s10404-020-02377-9
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Understanding flow distributions in human lungs has attracted significant attention since the last few decades. However, there are still large discrepancies between different studies in the distribution of air flow into alveoli at different generations of bifurcation. In this study, a new method has been developed to calculate expansion ratio of alveoli and ratio of alveolar to ductal flow rate at different generations for air- and saline-filled lungs. The effects of alveolar number, breathing period, lung tidal volume, and surface tension are examined. It is found that the expansion ratio of alveoli varies significantly at different generations in the saline-filled lungs. For the air-filled lung, the expansion ratio of individual alveolus remains constant for different generations. The current study provides new data on the flow rate ratios which is critical for understanding flow distributions and flow behaviors in alveoli. Surface tension in alveoli and alveolar number has obvious effects on the value of flow ratio. The current study sheds new light into the flow behavior in lungs and lays the foundation for detailed study on flow and particle transport characteristics in human lungs.
引用
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页数:13
相关论文
共 53 条
  • [1] Anderson JO, 2012, J MED TOXICOL, V8, P166, DOI 10.1007/s13181-011-0203-1
  • [2] Apone F, 2014, J INSECT SCI, V14, DOI 10.1673/031.014.87
  • [3] RELATIONS AMONG ALVEOLAR SURFACE-TENSION, SURFACE-AREA, VOLUME, AND RECOIL PRESSURE
    BACHOFEN, H
    SCHURCH, S
    URBINELLI, M
    WEIBEL, ER
    [J]. JOURNAL OF APPLIED PHYSIOLOGY, 1987, 62 (05) : 1878 - 1887
  • [4] Alveolar surface forces and lung architecture
    Bachofen, H
    Schürch, S
    [J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, 2001, 129 (01): : 183 - 193
  • [5] Barrett KE, 2016, GANONGS REV MED PHYS
  • [6] Flow field analysis in a compliant acinus replica model using particle image velocimetry (PIV)
    Berg, Emily J.
    Weisman, Jessica L.
    Oldham, Michael J.
    Robinson, Risa J.
    [J]. JOURNAL OF BIOMECHANICS, 2010, 43 (06) : 1039 - 1047
  • [7] Tracking X-ray microscopy for alveolar dynamics in live intact mice
    Chang, Soeun
    Kwon, Namseop
    Weon, Byung Mook
    Kim, Jinkyung
    Rhee, Chin Kook
    Choi, Han Sung
    Kohmura, Yoshiki
    Yamamoto, Masaki
    Ishikawa, Tetsuya
    Je, Jung Ho
    [J]. SCIENTIFIC REPORTS, 2013, 3
  • [8] Beyond PM2.5: The role of ultrafine particles on adverse health effects of air pollution
    Chen, Rui
    Hu, Bin
    Liu, Ying
    Xu, Jianxun
    Yang, Guosheng
    Xu, Diandou
    Chen, Chunying
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2016, 1860 (12): : 2844 - 2855
  • [9] Flow and Particle Dispersion in Lung Acini: Effect of Geometric and Dynamic Parameters During Synchronous Ventilation
    Chhabra, Sudhaker
    Prasad, Ajay K.
    [J]. JOURNAL OF FLUIDS ENGINEERING-TRANSACTIONS OF THE ASME, 2011, 133 (07):
  • [10] Fluid-structure analysis of microparticle transport in deformable pulmonary alveoli
    Dailey, H. L.
    Ghadiali, S. N.
    [J]. JOURNAL OF AEROSOL SCIENCE, 2007, 38 (03) : 269 - 288