Automation synthesis modules review

被引：55

作者：

Boschi, S. ^{[1
]}

Lodi, F. ^{[1
]}

Malizia, C. ^{[1
]}

Cicoria, G. ^{[2
]}

Marengo, M. ^{[2
]}

机构：

[1] S Orsola Malpighi Univ Hosp, Dept Nucl Med, PET Radiopharm, Bologna, Italy

[2] S Orsola Malpighi Univ Hosp, Bologna, Italy

来源：

APPLIED RADIATION AND ISOTOPES | 2013年 / 76卷

关键词：

Ga-68; Ge-68/Ga-68; generators; 8Ga-DOTA peptides; Neuroendocrine tumours; GA-68; PET; PEPTIDES;

D O I：

10.1016/j.apradiso.2012.09.010

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The introduction of Ga-68 labelled tracers has changed the diagnostic approach to neuroendocrine tumours and the availability of a reliable, long-lived Ge-68/Ga-68 generator has been at the bases of the development of Ga-68 radiopharmacy. The huge increase in clinical demand, the impact of regulatory issues and a careful radioprotection of the operators have boosted for extensive automation of the production process. The development of automated systems for Ga-68 radiochemistry, different engineering and software strategies and post-processing of the eluate were discussed along with impact of automation with regulations. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：38 / 45

页数：8

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