Cytologic Features of ALK-Positive Pulmonary Adenocarcinoma

被引：12

作者：

Ha, Seung Yeon ^{[1
]}

Ahn, Jungsuk ^{[1
]}

Roh, Mee Sook ^{[2
]}

Han, Joungho ^{[3
]}

Lee, Jae Jun ^{[3
]}

Lee, Boin ^{[3
]}

Yim, Jun ^{[4
]}

机构：

[1] Gachon Univ, Gil Med Ctr, Dept Pathol, Inchon, South Korea

[2] Dong A Univ, Coll Med, Dept Pathol, Pusan, South Korea

[3] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Pathol, Seoul 135710, South Korea

[4] Gachon Univ, Grad Sch Med, Dept Prevent Med, Inchon, South Korea

来源：

KOREAN JOURNAL OF PATHOLOGY | 2013年 / 47卷 / 03期

关键词：

Adenocarcinoma; Lung; Anaplastic lymphoma kinase; Carcinoma; non-small-cell lung; Cytology; SQUAMOUS-CELL CARCINOMA; LUNG ADENOCARCINOMA; EML4-ALK FUSION; CANCER; IDENTIFICATION; MUTATIONS;

D O I：

10.4132/KoreanJPathol.2013.47.3.252

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Background: The aim of this study was to determine the cytologic features of anaplastic lymphoma kinase (ALK) expressing pulmonary adenocarcinoma. Methods: We analyzed the cytopathological findings of 15 cases of endobronchial ultrasound guided aspiration and a case of bronchial washing. These cases were selected based on the histomorphology of ALK-rearranged lung adenocarcinoma. Results: Cytology showed mucinous (81.3%) and hemorrhagic (50%) backgrounds. The cells were arranged in tubulopapillary or tubulocribriform patterns (93.8%), and clusters (56.3%) admixed with signet ring cell features (87.5%). The tumor cells were monotonous and uniform with vesicular nuclei and a small nucleolus. Conclusions: The characteristic. findings were sheets showing a tubulopapillary or tubulocribriform appearance, with vesicular nuclei and a bland chromatin pattern (p<0.001). Scattered signet ring cells were helpful in suggesting ALK-positive adenocarcinoma (p<0.001).

引用

页码：252 / 257

页数：6

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