Facile, one-pot, four-component synthesis of a new series of imidazo[1,2-a]pyridines in presence of TPAB in EtOH under reflux conditions

被引：11
|
作者：
Etivand, Nasser [1 ]
Khalafy, Jabbar [1 ]
Marjani, Ahmad Poursattar [1 ]
机构：
[1] Urmia Univ, Dept Organ Chem, Fac Chem, Orumiyeh 5756151818, Iran
来源：
RESEARCH ON CHEMICAL INTERMEDIATES | 2019年 / 45卷 / 06期
关键词：
Imidazo[1; 2-a]pyridines; 2-Aminopyridine; Aryl glyoxal monohydrates; Ethyl acetoacetate; Hydrazine hydrate; One-pot four-component reaction; TPAB; MICROWAVE-ASSISTED SYNTHESIS; CATALYZED SYNTHESIS; DERIVATIVES; RECEPTOR; CONVENIENT; DISCOVERY; PYRIDINES; BINDING;
D O I：
10.1007/s11164-019-03797-1
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A convenient, regioselective, novel, and elegant one-pot, four-component reaction was designed for synthesis of a series of new of imidazo[1,2-a]pyridines using aryl glyoxal monohydrates, ethyl acetoacetate, hydrazine hydrate, and 2-aminopyridine in presence of tetrapropylammonium bromide under reflux in EtOH as solvent. The main advantages of this protocol include the availability and low cost of the starting materials, short reaction time, convenient operation, easy workup process, highly facile operation, nonhazardous byproducts, and high yield (82-94%). [GRAPHICS] .
引用
收藏
页码：3379 / 3394
页数：16
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