Awareness of hepatitis C virus infection status among people who inject drugs in a setting of universal direct-acting antiviral therapy: The ETHOS Engage study

被引：3

作者：

Valerio, Heather ^{[1
]}

Conway, Anna ^{[1
,2
]}

Alavi, Maryam ^{[1
]}

Treloar, Carla ^{[2
]}

Silk, David ^{[1
]}

Murray, Carolyn ^{[3
]}

Henderson, Charles ^{[4
]}

Amin, Janaki ^{[5
]}

Read, Phillip ^{[6
]}

Degenhardt, Louisa ^{[7
]}

Christmass, Michael ^{[8
,9
]}

Montebello, Mark ^{[10
]}

Dore, Gregory J. ^{[1
]}

Grebely, Jason ^{[1
]}

机构：

[1] UNSW Sydney, Kirby Inst, Sydney, NSW, Australia

[2] UNSW Sydney, Ctr Social Res Hlth, Sydney, NSW, Australia

[3] NSW Hlth, Populat Hlth Strategy & Performance, St Leonards, NSW, Australia

[4] NSW Users & AIDS Assoc, Surry Hills, NSW, Australia

[5] Macquarie Univ, Dept Hlth Sci, Sydney, NSW, Australia

[6] Kirketon Rd Ctr, Sydney, NSW, Australia

[7] UNSW Sydney, Natl Drug & Alcohol Res Ctr, Sydney, NSW, Australia

[8] Next Step Drug & Alcohol Serv, Perth, WA, Australia

[9] Curtin Univ, Natl Drug Res Inst, Perth, WA, Australia

[10] North Sydney Local Hlth Dist, Sydney, NSW, Australia

来源：

INTERNATIONAL JOURNAL OF DRUG POLICY | 2022年 / 110卷

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

Hepatitis C virus; People who inject drugs; Awareness; Infection status;

D O I：

10.1016/j.drugpo.2022.103876

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Background: Awareness of hepatitis C virus (HCV) infection status among people who inject drugs (PWID) can empower people with diagnosis, enable treatment uptake, and facilitate elimination. We aimed to evaluate aware-ness of HCV infection status among a large national cohort of PWID in an era of unrestricted HCV treatment. Methods: ETHOS Engage is an observational cohort study of PWID attending drug treatment clinics and needle and syringe programs in Australia. Participants completed a questionnaire containing self-reported HCV data (including infection status: never tested, tested/unknown, no current HCV infection [HCV RNA not detectable], current HCV infection [HCV RNA detectable]) and underwent point-of-care HCV RNA testing (Xpert (R) HCV Viral Load Fingerstick). Awareness was defined as concordant self-reported HCV status and test result. Awareness was assessed among all participants, those with current HCV infection, and participants who reported a lifetime history of HCV treatment. Logistic regression was used to assess factors associated with awareness in these three populations.Results: Among 2,305 PWID, 65% (n = 1,506) were aware of their HCV infection status (self-reported HCV status matched HCV point-of-care result). Awareness of infection status was higher among those who were not cur-rently infected (70%, n = 1,281/1,818) compared to those with current HCV infection (46%, n = 225/487). After adjusting, those with current HCV infection were less likely to be aware of infection status (aOR: 0.40, 95%CI: 0.30, 0.45). Among those who reported a lifetime history of HCV treatment, 71% (n = 592/829) were aware of their HCV infection status.Conclusion: Among a large cohort of PWID in Australia, awareness of HCV infection status is sub-optimal, with particularly concerning levels among those with active infection. Increased and simplified testing, post-test coun-selling, and post-treatment monitoring is warranted.

引用

页数：5