Pathophysiology of the disturbed angiogenesis in hemophilia

被引：5
作者：
Carlos Rodriguez-Merchan, E. [1 ]
机构：
[1] La Paz Univ Hosp, Dept Orthopaed Surg, Paseo Castellana 261, Madrid 28046, Spain
来源：
EXPERT REVIEW OF HEMATOLOGY | 2016年 / 9卷 / 10期
关键词：
Hemophilia; angiogenesis; antiangiogenic drugs; hemarthrosis; hemophilic arthropathy; ANTI-ANGIOGENESIS; ANTIANGIOGENIC THERAPY; IN-VITRO; INHIBITION; EXTRACT; ARTHROPATHY;
D O I：
10.1080/17474086.2016.1234933
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Introduction: It has been reported an increase of angiogenesis and vascular remodeling in hemophilic arthropathy. Therefore, antiangiogenic drugs could be useful in the management of hemophilic arthropathy. The aim of this review paper is to revise the role of angiogenesis in hemophilic arthropathy.Areas covered: This article is a narrative review of the pathophysiology of the disturbed angiogenesis in hemophilia and the potential role of antiangiogenic drugs in nonhemophilia patientsExpert commentary: Antiangiogenic drugs could be helpful in the future for the treatment of hemarthroses in hemophilic arthropathy. However, despite some recent reports emphasizing the role of angiogenesis in hemophilia, as these drugs have never been investigated for the treatment of hemophilic arthropathy in PWH, it is clear that they are not indicated.
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收藏
页码：933 / 938
页数：6
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