High risk cytogenetic abnormalities in patients with multiple myeloma

被引：3

作者：

Eugenia Legues, Maria ^{[1
,2
]}

Morales, Paulina ^{[1
]}

Valenzuela, Mercedes ^{[1
]}

Encina, Andrea ^{[1
]}

Jose Marti, Maria ^{[1
]}

Bascunan, Claudia ^{[1
]}

Cornejo, Paulina ^{[1
]}

Pena, Camila ^{[3
]}

Soledad Undurraga, Maria ^{[1
]}

机构：

[1] Hosp Salvador, Secc Hematol, Lab Citogenet, Santiago, Chile

[2] Univ Chile, Dept Med Interna Oriente, Av Salvador 486 1er Piso, Santiago, Chile

[3] Hosp Salvador, Unidad Hematol Clin, Santiago, Chile

来源：

REVISTA MEDICA DE CHILE | 2019年 / 147卷 / 01期

关键词：

Chromosome Aberrations; Cytogenetics; Multiple Myeloma;

D O I：

10.4067/S0034-98872019000100061

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Cytogenetic abnormalities observed in the bone marrow of patients with multiple myeloma (MM) are an important prognostic factor for risk stratification. Aim: To investigate karyotype characteristics and frequency of the high-risk cytogenetic abnormalities t(4;14), t( 14;16) and del(17p) in Chilean patients with MM. Material and Methods: We studied 30 patients with MM by conventional cytogenetics (CC) and fluorescent in situ hybridization of plasma cells selected using cytoplasmic immunoglobulin staining (cIg-FISH). Results: Overall, the two techniques in combination allowed us to identify clonal genetic abnormalities in 47% of patients. The t(4;14) abnormality was observed in 19% of patients, del( 17p) was observed in 10% of patients, and t(14;16) was not detected. Conclusions: Our results showed frequencies of high-risk abnormalities similar to those reported abroad. Cytogenetic studies should be performed routinely for all MM patients at the moment of diagnosis.

引用

页码：61 / 64

页数：4

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