Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection

被引：384
作者：
Bertoletti, Antonio [2 ,3 ,4 ]
Ferrari, Carlo [1 ]
机构：
[1] Azienda Osped Univ Parma, Unit Infect Dis & Hepatol, Lab Viral Immunopathol, I-43100 Parma, Italy
[2] ASTAR, Infect & Immun Program, Singapore Inst Clin Sci, Singapore, Singapore
[3] Duke NUS Grad Med Sch, Program Emerging Viral Dis, Singapore, Singapore
[4] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore 117595, Singapore
来源：
GUT | 2012年 / 61卷 / 12期
关键词：
REGULATORY T-CELLS; TLR7 AGONIST GS-9620; HUMAN HEPATOCYTES; INTERFERON-ALPHA; LONGITUDINAL ANALYSIS; LAMIVUDINE TREATMENT; GENOMIC ANALYSIS; SURFACE-ANTIGEN; HOST RESPONSE; LIVER-DAMAGE;
D O I：
10.1136/gutjnl-2011-301073
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Knowledge of the immunological events necessary to control hepatitis B virus (HBV) infection has accelerated in recent years, but their translation towards therapeutic strategies able to achieve a durable HBV suppression has been challenging. The scenario of how HBV deals with the host immunity is presented and used to discuss how the immune response can be harnessed to potentially achieve infection control.
引用
收藏
页码：1754 / 1764
页数：11
相关论文
共 121 条
  • [1] Comparison of Immune Restoration in Early versus Late Alpha Interferon Therapy against Hepatitis C Virus
    Abdel-Hakeem, Mohamed S.
    Bedard, Nathalie
    Badr, Gamal
    Ostrowski, Mario
    Sekaly, Rafick P.
    Bruneau, Julie
    Willems, Bernard
    Heathcote, E. Jenny
    Shoukry, Naglaa H.
    [J]. JOURNAL OF VIROLOGY, 2010, 84 (19) : 10429 - 10435
  • [2] Pathogen recognition and innate immunity
    Akira, S
    Uematsu, S
    Takeuchi, O
    [J]. CELL, 2006, 124 (04) : 783 - 801
  • [3] The Size of the Viral Inoculum Contributes to the Outcome of Hepatitis B Virus Infection
    Asabe, Shinichi
    Wieland, Stefan F.
    Chattopadhyay, Pratip K.
    Roederer, Mario
    Engle, Ronald E.
    Purcell, Robert H.
    Chisari, Francis V.
    [J]. JOURNAL OF VIROLOGY, 2009, 83 (19) : 9652 - 9662
  • [4] Hepatitis B and C Virus Coinfection: A Novel Model System Reveals the Absence of Direct Viral Interference
    Bellecave, Pantxika
    Gouttenoire, Jerome
    Gajer, Markus
    Brass, Volker
    Koutsoudakis, George
    Blum, Hubert E.
    Bartenschlager, Ralf
    Nassal, Michael
    Moradpour, Darius
    [J]. HEPATOLOGY, 2009, 50 (01) : 46 - 55
  • [5] Kinetics of the immune response during HBV and HCV infection
    Bertoletti, A
    Ferrari, C
    [J]. HEPATOLOGY, 2003, 38 (01) : 4 - 13
  • [6] The host-pathogen interaction during HBV infection: immunological controversies
    Bertoletti, Antonio
    Maini, Mala K.
    Ferrari, Carlo
    [J]. ANTIVIRAL THERAPY, 2010, 15 : 15 - 24
  • [7] Bertoletti Antonio, 2009, Expert Rev Gastroenterol Hepatol, V3, P561, DOI 10.1586/egh.09.48
  • [8] Bertolino P, 1998, EUR J IMMUNOL, V28, P221, DOI 10.1002/(SICI)1521-4141(199801)28:01<221::AID-IMMU221>3.0.CO
  • [9] 2-F
  • [10] Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties
    Billerbeck, Eva
    Kang, Yu-Hoi
    Walker, Lucy
    Lockstone, Helen
    Grafmueller, Stefanie
    Fleming, Vicki
    Flint, Jonathan
    Willberg, Chris B.
    Bengsch, Bertram
    Seigel, Bianca
    Ramamurthy, Narayan
    Zitzmann, Nicole
    Barnes, Eleanor J.
    Thevanayagam, Jonarthan
    Bhagwanani, Anisha
    Leslie, Alasdair
    Oo, Ye H.
    Kollnberger, Simon
    Bowness, Paul
    Drognitz, Oliver
    Adams, David H.
    Blum, Hubert E.
    Thimme, Robert
    Klenerman, Paul
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (07) : 3006 - 3011
12345678910