Longitudinal study of seroprevalence and serostability of 34 human papillomavirus types in European organ transplant recipients

被引：9

作者：

Antonsson, Annika ^{[1
]}

Waterboer, Tim ^{[2
]}

Bavinck, Jan N. Bouwes ^{[3
]}

Abeni, Damiano ^{[4
]}

de Koning, Maurits ^{[5
]}

Euvrard, Sylvie ^{[6
]}

Feltkamp, Mariet C. W. ^{[7
]}

Green, Adele C. ^{[1
,8
]}

Harwood, Catherine A. ^{[9
]}

Naldi, Luigi ^{[10
]}

Nindl, Ingo ^{[11
]}

Pfister, Herbert J. ^{[12
]}

Proby, Charlotte M. ^{[9
]}

Quint, Wim G. ^{[5
]}

Stockfleth, Eggert ^{[11
]}

Weissenborn, Soenke J. ^{[12
]}

Pawlita, Michael ^{[2
]}

Neale, Rachel E. ^{[1
]}

机构：

[1] Queensland Inst Med Res, Dept Populat Hlth, Brisbane, Qld 4006, Australia

[2] German Canc Res Ctr, Infect & Canc Program, Heidelberg, Germany

[3] Leiden Univ, Med Ctr, Dept Dermatol, Leiden, Netherlands

[4] IRCCS, IDI, Rome, Italy

[5] DDL Diagnost Lab, Voorburg, Netherlands

[6] Hop Edouard Herriot, Dept Dermatol, Lyon, France

[7] Leiden Univ, Med Ctr, Dept Med Microbiol, Leiden, Netherlands

[8] Univ Manchester, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England

[9] Queen Mary Univ London, Barts & London Sch Med & Dent, London, England

[10] Osped Riuniti Bergamo, I-24100 Bergamo, Italy

[11] Univ Hosp Berlin, Skin Canc Ctr Charite, Dept Dermatol, Berlin, Germany

[12] Univ Cologne, Inst Virol, D-50931 Cologne, Germany

来源：

VIROLOGY | 2013年 / 436卷 / 01期

基金：

英国医学研究理事会;

关键词：

Human papillomavirus; Serology; Organ transplanted recipients; Longitudinal study; Seroprevalence; Antibody stability; SQUAMOUS-CELL CARCINOMA; NONMELANOMA SKIN-CANCER; CUTANEOUS HUMAN PAPILLOMAVIRUSES; GLUTATHIONE-S-TRANSFERASE; RISK-FACTORS; BETAPAPILLOMAVIRUS INFECTION; ANTIBODY-RESPONSES; E6/E7; EXPRESSION; PREVALENCE; WOMEN;

D O I：

10.1016/j.virol.2012.10.037

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Organ transplant recipients (OTR) are at increased risk of cutaneous squamous cell carcinoma, which may be related to reactivation of human papillomavirus (HPV) infections. Measurement of change in HPV antibodies after transplantation would help to explore this hypothesis. We measured antibodies to 34 HPV types on up to six occasions over 18 months in 441 OTRs from five European countries. At baseline (mean 24 days after transplantation), 80% of all OTRs were seropositive to at least one HPV type. The beta HPV genus had the highest seroprevalence (45%). For most HPV genera baseline seroprevalence peaked between 40 and 59 years old. Most OTRs retained their serostatus over time and antibody levels were stable. Seroprevalence in immunosuppressed OTRs is stable in the 18 months immediately after transplantation. Thus there is no short-term evidence that immunosuppression leads to new or reactivated skin infection with HPV sufficient to induce antibodies. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：91 / 99

页数：9

共 54 条

[1] Cancer risk following organ transplantation:: a nationwide cohort study in Sweden [J].

Adami, J ;

Gäbel, H ;

Lindelöf, B ;

Ekström, K ;

Rydh, B ;

Glimelius, B ;

Ekbom, A ;

Adami, HO ;

Granath, F .

BRITISH JOURNAL OF CANCER, 2003, 89 (07) :1221-1227

[2]

af Geijersstam V, 1998, J INFECT DIS, V177, P1710, DOI 10.1086/517428

[3] UV-B irradiation stimulates the promoter activity of the high-risk, cutaneous human papillomavirus 5 and 8 in primary keratinocytes [J].

Akgül, B ;

Lemme, W ;

García-Escudero, R ;

Storey, A ;

Pfister, HJ .

ARCHIVES OF VIROLOGY, 2005, 150 (01) :145-151

[4] Seroreactivity to cutaneous human papillomaviruses among patients with nonmelanoma skin cancer or benign skin lesions [J].

Andersson, Kristin ;

Waterboer, Tim ;

Kirnbauer, Reinhard ;

Slupetzky, Katharina ;

Iftner, Thomas ;

de Villiers, Ethel-Michele ;

Forslund, Ola ;

Pawlita, Michael ;

Dillner, Joakim .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2008, 17 (01) :189-195

[5] The ubiquity and impressive genomic diversity of human skin papillomaviruses suggest a commensalic nature of these viruses [J].

Antonsson, A ;

Forslund, O ;

Ekberg, H ;

Sterner, G ;

Hansson, BG .

JOURNAL OF VIROLOGY, 2000, 74 (24) :11636-11641

[6] Prevalence and stability of antibodies to 37 human papillomavirus types - A population-based longitudinal study [J].

Antonsson, Annika ;

Green, Adele C. ;

Mallitt, Kylie-ann ;

O'Rourke, Peter K. ;

Pandeya, Nirmala ;

Pawlita, Michael ;

Waterboer, Tim ;

Neale, Rachel E. .

VIROLOGY, 2010, 407 (01) :26-32

[7] Keratotic skin lesions and other risk factors are associated with skin cancer in organ-transplant recipients: A case-control study in the Netherlands, United Kingdom, Germany, France, and Italy [J].

Bavinck, Jan N. Bouwes ;

Euvrard, Sylvie ;

Naldi, Luigi ;

Nindl, Ingo ;

Proby, Charlotte M. ;

Neale, Rachel ;

Abeni, Damiano ;

Tessari, Gian P. ;

Feltkamp, Mariet C. W. ;

Claudy, Alain ;

Stockfleth, Eggert ;

Harwood, Catherine A. .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2007, 127 (07) :1647-1656

[8] Multicenter Study of the Association between Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma [J].

Bavinck, Jan Nico Bouwes ;

Neale, Rachel E. ;

Abeni, Damiano ;

Euvrard, Sylvie ;

Green, Adele C. ;

Harwood, Catherine A. ;

de Koning, Maurits N. C. ;

Naldi, Luigi ;

Nindl, Ingo ;

Pawlita, Michael ;

Pfister, Herbert ;

Proby, Charlotte M. ;

Quint, Wim G. V. ;

ter Schegget, Jan ;

Waterboer, Tim ;

Weissenborn, Soenke ;

Feltkamp, Mariet C. W. .

CANCER RESEARCH, 2010, 70 (23) :9777-9786

[9] Human papillomavirus infection and skin cancer risk in organ transplant recipients [J].

Bavinck, JNB ;

Feltkamp, M ;

Struijk, L ;

ter Schegget, J .

JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS, 2001, 6 (03) :207-211

[10] Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendments [J].

Bernard, Hans-Ulrich ;

Burk, Robert D. ;

Chen, Zigui ;

van Doorslaer, Koenraad ;

zur Hausen, Harald ;

de Villiers, Ethel-Michele .

VIROLOGY, 2010, 401 (01) :70-79

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