Preserved CD4 T-cell telomere length during long-lasting HIV-2 infection

被引：3

作者：

Tendeiro, Rita ^{[1
]}

Albuquerque, Adriana S. ^{[1
]}

Foxall, Russell B. ^{[1
]}

Cavaleiro, Rita ^{[1
]}

Soares, Rui S. ^{[1
]}

Baptista, Antonio P. ^{[1
]}

Soares, Maria V. D. ^{[1
]}

Gomes, Perpetua ^{[2
,3
,4
]}

Sousa, Ana E. ^{[1
]}

机构：

[1] Univ Lisbon, Fac Med, Inst Med Mol, Unidade Imunol Clin, P-1649028 Lisbon, Portugal

[2] Inst Super Ciencias Saude Egas Moniz, Ctr Invest Interdisciplinar Egas Moniz CiiEM, Caparica, Portugal

[3] Univ Nova Lisboa, Hosp Egas Moniz, Ctr Hosp Lisboa Ocidental, Lab Biol Mol,Serv Med Transfus, P-1200 Lisbon, Portugal

[4] Univ Nova Lisboa, Inst Higiene & Med Trop, Ctr Malaria & Doencas Trop, P-1200 Lisbon, Portugal

来源：

AIDS | 2013年 / 27卷 / 02期

关键词：

HIV-2-INFECTED PATIENTS; ANTIRETROVIRAL THERAPY; TYPE-1; INFECTION; NAIVE; PATHOGENESIS; DEPLETION; DISEASE; ACTIVATION; SENESCENCE; EXPRESSION;

D O I：

10.1097/QAD.0b013e32835ab234

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

HIV-2 infection features a much slower course than HIV-1 infection, often asymptomatic for over 20 years, without antiretroviral therapy (ART). Nevertheless, CD4 T cells progressively decline, in direct correlation with immune activation and cell cycling. We report, for the first time, preserved telomere length within naive and memory CD4 subsets in prolonged HIV-2 infection despite the increased CD4 turnover.

引用

页码：289 / 292

页数：4

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