Pd(II)-Catalyzed C-H Acylation of (Hetero)arenes-Recent Advances

被引：20

作者：

Santiago, Carlos ^{[1
]}

Sotomayor, Nuria ^{[1
]}

Lete, Esther ^{[1
]}

机构：

[1] Univ Pais Vasco Euskal Herriko Unibertsitatea UPV, Fac Ciencia & Tecnol, Dept Quim Organ 2, Apdo 644, Bilbao 48080, Spain

来源：

MOLECULES | 2020年 / 25卷 / 14期

关键词：

C-H activation; acylation; palladium; arenes; heteroarenes; DECARBOXYLATIVE ORTHO-ACYLATION; ALPHA-OXOCARBOXYLIC ACIDS; PALLADIUM-CATALYZED ACYLATION; VISIBLE-LIGHT PHOTOREDOX; N-NITROSOANILINES; DIRECT ACCESS; BOND ACYLATION; C-2; ACYLATION; ALDEHYDES; INDOLES;

D O I：

10.3390/molecules25143247

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Di(hetero)aryl ketones are important motifs present in natural products, pharmaceuticals or agrochemicals. In recent years, Pd(II)-catalyzed acylation of (hetero)arenes in the presence of an oxidant has emerged as a catalytic alternative to classical acylation methods, reducing the production of toxic metal waste. Different directing groups and acyl sources are being studied for this purpose, although further development is required to face mainly selectivity problems in order to be applied in the synthesis of more complex molecules. Selected recent developments and applications are covered in this review.

引用

页数：19

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