Chemical Constituents from Andrographis echioides and Their Anti-Inflammatory Activity

被引:17
作者
Shen, De-Yang [1 ]
Juang, Shin-Hun [2 ]
Kuo, Ping-Chung [3 ]
Huang, Guan-Jhong [4 ]
Chan, Yu-Yi [5 ]
Damu, Amooru G. [1 ]
Wu, Tian-Shung [1 ,4 ,6 ]
机构
[1] Natl Cheng Kung Univ, Dept Chem, Tainan 70101, Taiwan
[2] China Med Univ, Grad Inst Pharmaceut Chem, Taichung 40402, Taiwan
[3] Natl Formosa Univ, Dept Biotechnol, Yunlin 632, Taiwan
[4] China Med Univ, Dept Pharm, Taichung 40402, Taiwan
[5] So Taiwan Univ Sci & Technol, Dept Biotechnol, Tainan 71005, Taiwan
[6] China Med Univ Hosp, Chinese Med Res & Dev Ctr, Taichung 40402, Taiwan
来源
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2013年 / 14卷 / 01期
关键词
Andrographis echioides; flavonoid; anti-inflammatory; iNOS; NITRIC-OXIDE PRODUCTION; BIOACTIVE CONSTITUENTS; 2-OXYGENATED FLAVONES; ARTEMISIA-ANNUA; PANICULATA NEES; GLYCOSIDES; ESTERS; DITERPENOIDS; DERIVATIVES; FLAVANONES;
D O I
10.3390/ijms14010496
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Phytochemical investigation of the whole plants of Andrographis echioides afforded two new 2'-oxygenated flavonoids (1) and (2), two new phenyl glycosides (3) and (4), along with 37 known structures. The structures of new compounds were elucidated by spectral analysis and chemical transformation studies. Among the isolated compounds, (1-2) and (6-19) were subjected into the examination for their iNOS inhibitory bioactivity. The structure-activity relationships of the flavonoids for their inhibition of NO production were also discussed.
引用
收藏
页码:496 / 514
页数:19
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