Chemical Constituents from Andrographis echioides and Their Anti-Inflammatory Activity

被引：17

作者：

Shen, De-Yang ^{[1
]}

Juang, Shin-Hun ^{[2
]}

Kuo, Ping-Chung ^{[3
]}

Huang, Guan-Jhong ^{[4
]}

Chan, Yu-Yi ^{[5
]}

Damu, Amooru G. ^{[1
]}

Wu, Tian-Shung ^{[1
,4
,6
]}

机构：

[1] Natl Cheng Kung Univ, Dept Chem, Tainan 70101, Taiwan

[2] China Med Univ, Grad Inst Pharmaceut Chem, Taichung 40402, Taiwan

[3] Natl Formosa Univ, Dept Biotechnol, Yunlin 632, Taiwan

[4] China Med Univ, Dept Pharm, Taichung 40402, Taiwan

[5] So Taiwan Univ Sci & Technol, Dept Biotechnol, Tainan 71005, Taiwan

[6] China Med Univ Hosp, Chinese Med Res & Dev Ctr, Taichung 40402, Taiwan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2013年 / 14卷 / 01期

关键词：

Andrographis echioides; flavonoid; anti-inflammatory; iNOS; NITRIC-OXIDE PRODUCTION; BIOACTIVE CONSTITUENTS; 2-OXYGENATED FLAVONES; ARTEMISIA-ANNUA; PANICULATA NEES; GLYCOSIDES; ESTERS; DITERPENOIDS; DERIVATIVES; FLAVANONES;

D O I：

10.3390/ijms14010496

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phytochemical investigation of the whole plants of Andrographis echioides afforded two new 2'-oxygenated flavonoids (1) and (2), two new phenyl glycosides (3) and (4), along with 37 known structures. The structures of new compounds were elucidated by spectral analysis and chemical transformation studies. Among the isolated compounds, (1-2) and (6-19) were subjected into the examination for their iNOS inhibitory bioactivity. The structure-activity relationships of the flavonoids for their inhibition of NO production were also discussed.

引用

页码：496 / 514

页数：19

共 55 条

[1]

Balmain A, 1973, J CHEM SOC P1, V1, P1247

[2]

BARBOSA-FILHO JM, 1987, PHYTOCHEMISTRY, V26, P2615, DOI 10.1016/S0031-9422(00)83890-X

[3] Terpenoids from the seeds of Artemisia annua [J].

Brown, GD ;

Liang, GY ;

Sy, LK .

PHYTOCHEMISTRY, 2003, 64 (01) :303-323

[4] PHYTENE-1,2-DIOL FROM ARTEMISIA-ANNUA [J].

BROWN, GD .

PHYTOCHEMISTRY, 1994, 36 (06) :1553-1554

[5] Bioactive Constituents from the Roots of Panax japonicus var. major and Development of a LC-MS/MS Method for Distinguishing between Natural and Artifactual Compounds [J].

Chan, Hsiu-Hui ;

Hwang, Tsong-Long ;

Reddy, Mopur Vijaya Bhaskar ;

Li, Ding-Tzai ;

Qian, Keduo ;

Bastow, Kenneth F. ;

Lee, Kuo-Hsiung ;

Wu, Tian-Shung .

JOURNAL OF NATURAL PRODUCTS, 2011, 74 (04) :796-802

[6] STRUCTURE AND STEREOCHEMISTRY OF NEOANDROGRAPHOLIDE, A DITERPENE GLUCOSIDE FROM ANDROGRAPHIS-PANICULATA NEES [J].

CHAN, WR ;

TAYLOR, DR ;

WILLIS, CR ;

BODDEN, RL ;

FEHLHABER, HW .

TETRAHEDRON, 1971, 27 (21) :5081-+

[7] Anti-inflammatory activities of tormentic acid from suspension cells of Eriobotrya Japonica ex vivo and in vivo [J].

Chang, Chwen-Tzuei ;

Huang, Shyh-Shyun ;

Lin, Shiang-Shiou ;

Amagaya, Sakae ;

Ho, Hui-Ya ;

Hou, Wen-Chi ;

Shie, Pei-Hsin ;

Wu, Jin-Bin ;

Huang, Guan-Jhong .

FOOD CHEMISTRY, 2011, 127 (03) :1131-1137

[8] Antiviral and Anti-inflammatory Metabolites from the Soft Coral Sinularia capillosa [J].

Cheng, Shi-Yie ;

Huang, Ki-Jhih ;

Wang, Shang-Kwei ;

Wen, Zhi-Horng ;

Chen, Pei-Wen ;

Duh, Chang-Yih .

JOURNAL OF NATURAL PRODUCTS, 2010, 73 (04) :771-775

[9]

Chopra RN, 1980, GLOSSARY INDIAN MED, P18

[10] Cytotoxic Flavonoids from the Leaves of Cryptocarya chinensis [J].

Chou, Tsung-Hsien ;

Chen, Jih-Jung ;

Lee, Shiow-Ju ;

Chiang, Michael Y. ;

Yang, Cheng-Wei ;

Chen, Ih-Sheng .

JOURNAL OF NATURAL PRODUCTS, 2010, 73 (09) :1470-1475

← 1 2 3 4 5 6 →