A New Hope: Self-Assembling Peptides with Antimicrobial Activity

被引：99

作者：

Lombardi, Lucia ^{[1
]}

Falanga, Annarita ^{[2
]}

Del Genio, Valentina ^{[1
]}

Galdiero, Stefania ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Pharm, Via Mezzocannone 16, I-80134 Naples, Italy

[2] Univ Naples Federico II, Dept Agr Sci, Via Mezzocannone 16, I-80134 Naples, Italy

来源：

PHARMACEUTICS | 2019年 / 11卷 / 04期

关键词：

self-assembling; peptide; antimicrobial activity; nanomaterial; ANTIBACTERIAL PROPERTIES; QUANTUM DOTS; HYDROGELS; DESIGN; NANOPARTICLES; NANOFIBERS; ANALOG; FABRICATION; INDOLICIDIN; MECHANISMS;

D O I：

10.3390/pharmaceutics11040166

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Peptide drugs hold great promise for the treatment of infectious diseases thanks to their novel mechanisms of action, low toxicity, high specificity, and ease of synthesis and modification. Naturally developing self-assembly in nature has inspired remarkable interest in self-assembly of peptides to functional nanomaterials. As a matter of fact, their structural, mechanical, and functional advantages, plus their high bio-compatibility and bio-degradability make them excellent candidates for facilitating biomedical applications. This review focuses on the self-assembly of peptides for the fabrication of antibacterial nanomaterials holding great interest for substituting antibiotics, with emphasis on strategies to achieve nano-architectures of self-assembly. The antibacterial activities achieved by these nanomaterials are also described.

引用

页数：17

共 115 条

[1] Self-Assembled Peptide- and Protein-Based Nanomaterials for Antitumor Photodynamic and Photothermal Therapy [J].