Analysis of HIV type 1 subtype C full-length gag gene sequences from India:: Novel observations and plausible implications

被引：17
作者：
Gupta, RM
Prasad, VVSP
Rai, A
Seth, P [1 ]
机构：
[1] Armed Forces Med Coll, Dept Microbiol, Pune, Maharashtra, India
[2] All India Inst Med Sci, Dept Microbiol, New Delhi 110029, India
[3] Natl Inst Communicable Dis, Dept Biotechnol, New Delhi, India
来源：
AIDS RESEARCH AND HUMAN RETROVIRUSES | 2005年 / 21卷 / 12期
关键词：
D O I：
10.1089/aid.2005.21.1066
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Twenty-four HIV-1 gag genes from patients in India were sequenced and analyzed. All measured 1476-1491 nucleotides with an average of 1483 nucleotides in length. Phylogenetic analysis revealed a homogeneous epidemic of HIV-1 subtype C. Intragenotypic divergence of up to 6.6% was present. Fourteen novel conserved signature pattern residues were delineated for HIV-1 subtype C strains. Each of the 15 nucleocapsid (NC) basic residues was highly conserved p6 gag LXSLFG and PT/SAPP motifs were highly conserved except for PTVPT in three and PTAPT in two strains. Zinc ringer motifs were conserved in all. Documented HIV-1 subtype C gag immunodominant CTL epitopes were conserved. The evolving predominance and the change in nature of the epidemic from Thai B to that of subtype C in the Northeastern regions of India were observed. Tracking the evolution of the Indian epidemic has implications for developing a vaccine.
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收藏
页码：1066 / 1072
页数：7
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