Translating Molecular Recognition into a Pressure Signal to enable Rapid, Sensitive, and Portable Biomedical Analysis

被引：163

作者：

Zhu, Zhi ^{[1
]}

Guan, Zhichao ^{[1
]}

Liu, Dan ^{[1
]}

Jia, Shasha ^{[1
]}

Li, Jiuxing ^{[1
]}

Lei, Zhichao ^{[1
]}

Lin, Shuichao ^{[1
]}

Ji, Tianhai ^{[1
]}

Tian, Zhongqun ^{[1
]}

Yang, Chaoyong James ^{[1
]}

机构：

[1] Xiamen Univ, State Key Lab Phys Chem Solid Surfaces,Coll Chem, MOE Key Lab Spectrochem Anal & Instrumentat,Dept, Collaborat Innovat Ctr Chem Energy Mat,Key Lab Ch, Xiamen 361005, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2015年 / 54卷 / 36期

基金：

美国国家科学基金会;

关键词：

gas generation; hydrogen peroxide; immunoassay; point-of-care testing; pressure measurement; OF-CARE DIAGNOSTICS; BAR-CHART CHIP; POINT; GLUCOSE; PAPER; HYDROGEL; READOUT; DEVICES; TARGETS; SENSOR;

D O I：

10.1002/anie.201503963

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, we demonstrate that a very familiar, yet underutilized, physical parametergas pressurecan serve as signal readout for highly sensitive bioanalysis. Integration of a catalyzed gas-generation reaction with a molecular recognition component leads to significant pressure changes, which can be measured with high sensitivity using a low-cost and portable pressure meter. This new signaling strategy opens up a new way for simple, portable, yet highly sensitive biomedical analysis in a variety of settings.

引用

收藏

页码：10448 / +

页数：6

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