Once daily insulin detemir in cystic fibrosis with insulin deficiency

被引：38
作者：
Hameed, Shihab [1 ,2 ]
Morton, John R. [2 ,3 ]
Field, Penny I. [3 ]
Belessis, Yvonne [2 ,3 ]
Yoong, Terence [3 ]
Katz, Tamarah [3 ]
Woodhead, Helen J. [1 ,2 ]
Walker, Jan L. [1 ,2 ]
Neville, Kristen A. [1 ,2 ]
Campbell, Thomas A. [1 ]
Jaffe, Adam [2 ,3 ]
Verge, Charles F. [1 ,2 ]
机构：
[1] Sydney Childrens Hosp, Dept Endocrinol, Randwick, NSW 2031, Australia
[2] Univ New S Wales, Sch Womens & Childrens Hlth, Randwick, NSW, Australia
[3] Sydney Childrens Hosp, Dept Resp Med, Randwick, NSW 2031, Australia
来源：
ARCHIVES OF DISEASE IN CHILDHOOD | 2012年 / 97卷 / 05期
关键词：
GLARGINE; ADOLESCENTS; CHILDREN;
D O I：
10.1136/adc.2010.204636
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
The aim of this study was to determine if once daily insulin detemir reverses decline in weight and lung function in patients with cystic fibrosis (CF). 12 patients with early insulin deficiency and six with CF related diabetes (aged 7.2-18.1 years) were treated for a median of 0.8 years. Changes in weight and lung function following treatment were compared to pretreatment changes. Before treatment, the change in weight SD score (Delta WtSDS), percentage of predicted forced expiratory volume in 1 s (Delta%FEV1) and percentage of predicted forced vital capacity (Delta%FVC) declined in the whole study population (-0.45 +/- 0.38, -7.9 +/- 12.8%, -5.8 +/- 14.3%) and in the subgroup with early insulin deficiency (-0.41 +/- 0.43, -9.8 +/- 9.3%, -6.8 +/- 10.3%). Following treatment with insulin Delta WtSDS, Delta%FEV1 and Delta%FVC significantly improved in the whole study population (+0.18 +/- 0.29 SDS, p=0.0001; +3.7 +/- 10.6%, p=0.007; +5.2 +/- 12.7%, p=0.013) and in patients with early insulin deficiency (+0.22 +/- 0.31 SDS, p=0.003; +5.3 +/- 11.5%, p=0.004; +5.8 +/- 13.4%, p=0.024). Randomised controlled trials are now needed.
引用
收藏
页码：464 / 467
页数：4
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