Wnt signaling in planarians: new answers to old questions

被引：41
作者：
Almuedo-Castillo, Maria
Sureda-Gomez, Miquel
Adell, Teresa [1 ,2 ]
机构：
[1] Univ Barcelona, Dept Genet, E-08028 Barcelona, Spain
[2] Univ Barcelona, Inst Biomed, E-08028 Barcelona, Spain
来源：
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY | 2012年 / 56卷 / 1-3期
关键词：
planarian; Wnt signalling; regeneration; development; axial polarity; BETA-CATENIN; CELL POLARITY; BLASTEMA POLARITY; GENE-EXPRESSION; AXIS FORMATION; WOUND CLOSURE; REGENERATION; HEAD; DYNAMICS; COMMUNICATION;
D O I：
10.1387/ijdb.113451ma
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Wnts are secreted glycoproteins involved in a broad range of essential cell functions, including proliferation, migration and cell-fate determination. Recent years have seen substantial research effort invested in elucidating the role of theWnt signaling pathway in planarians, flatworms with incredible regenerative capacities. In this review, we summarize current knowledge on the role of canonical (beta-catenin-dependent) and non-canonical (beta-catenin-independent) Wnt signaling in planarians, not only during regeneration, but also during normal homeostasis. We also describe some of the preliminary data that has been obtained regarding the role of these pathways during embryogenesis. Models are proposed to integrate the different results which have been obtained to date and highlight those questions that still remain to be answered.
引用
收藏
页码：53 / 65
页数：13
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