Modeling Process Partitioning of Biomolecules in Polymer-Polymer and Polymer-Salt Aqueous Two-Phase Systems (ATPS) using an Extended Excess Gibbs Energy Model

被引：15
作者：
Pazuki, G. R. [1 ]
Taghikhani, V. [1 ]
Vossoughi, M. [1 ,2 ]
机构：
[1] Sharif Univ Technol, Dept Chem & Petr Engn, Tehran, Iran
[2] Sharif Univ Technol, Inst Nanosci & Nanotechnol, Tehran, Iran
来源：
ZEITSCHRIFT FUR PHYSIKALISCHE CHEMIE-INTERNATIONAL JOURNAL OF RESEARCH IN PHYSICAL CHEMISTRY & CHEMICAL PHYSICS | 2009年 / 223卷 / 03期
关键词：
Partitioning; Biomolecule; Aqueous Two-Phase Systems; Gibbs Energy Model; LIQUID-LIQUID EQUILIBRIA; MOLECULAR THERMODYNAMICS; HYDROLYTIC ENZYMES; GLYCOL; COEFFICIENTS;
D O I：
10.1524/zpch.2009.5421
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A new local composition model was used to study the phase behavior of polymer-polymer and polymer-salt aqueous two-phase systems. The proposed model has three terms which account for the combinatorial, the long-range and the short-range effects in solution. The Flory-Huggins and the Debye-Huckel models were used for the combinatorial and long-range contributions. The interaction parameters of the model studied in this work can be regressed using a non-liner regression between the experimental data and those obtained from the proposed model. Also, this model was applied for modeling the partitioning of biomolecules in polymer-polymer and polymer-salt aqueous two-phase systems. The results showed that the proposed model has a good accuracy in correlating the partitioning coefficients of biomolecules in aqueous two-phase systems.
引用
收藏
页码：263 / 278
页数：16
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