Extended-spectrum beta-lactamase-producing and carbapenemase-producing Enterobacter cloacae ventriculitis successfully treated with intraventricular colistin

被引：12

作者：

Cascio, Antonio ^{[1
]}

Mezzatesta, Maria Lina ^{[2
]}

Odierna, Antonino ^{[3
]}

Di Bernardo, Francesca ^{[4
]}

Barberi, Giuseppina ^{[1
]}

Iaria, Chiara ^{[5
]}

Stefani, Stefania ^{[2
]}

Giordano, Salvatore ^{[6
]}

机构：

[1] Univ Messina, Dept Human Pathol, I-98125 Messina, Italy

[2] Univ Catania, Microbiol Sect, Dept Biomed Sci, Catania, Italy

[3] ARNAS Gen Hosp Civ Di Cristina Benfratelli, Neurosurg Unit, Palermo, Italy

[4] ARNAS Gen Hosp Civ Di Cristina & Benfratelli, Microbiol Lab, Palermo, Italy

[5] Azienda Osped Piemonte Papardo, Infect Dis Unit, Messina, Italy

[6] ARNAS Gen Hosp Civ Di Cristina Benfratelli, Infect Dis Unit, Palermo, Italy

来源：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2014年 / 20卷

关键词：

Carbapenemases; Colistin; Enterobacteriaceae; Enterobacter cloacae; Intraventricular; Meningitis; Ventriculitis; CEREBROSPINAL-FLUID;

D O I：

10.1016/j.ijid.2013.11.012

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We present a case of post-neurosurgical ventriculitis caused by carbapenemase-producing Enterobacter cloacae successfully treated with intraventricular colistin. Enterobacter spp are intrinsically resistant to aminopenicillins, cefazolin, and cefoxitin due to the production of constitutive chromosomal AmpC beta-lactamases. Moreover, extended-spectrum beta-lactamase-producing Enterobacter spp have been identified in the USA and Europe, and carbapenems are considered the drug of choice in these cases. Our isolate was sensitive only to fosfomycin, tigecycline, and colistin, and 6 days of intravenous colistin had failed to eradicate the infection. This case provides clinical evidence to support the administration of intraventricular colistin in such patients. (C) 2013 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. All rights reserved.

引用

页码：66 / 67

页数：2

共 5 条

[1] Post-neurosurgical multidrug-resistant Acinetobacter baumannii meningitis successfully treated with intrathecal colistin. A new case and a systematic review of the literature [J].