A Ca2+ Sensor for Exocytosis

被引：19
|
作者：
Chapman, Edwin R. [1 ,2 ]
机构：
[1] Univ Wisconsin, Dept Neurosci, 1111 Highland Ave, Madison, WI 53705 USA
[2] Univ Wisconsin, Howard Hughes Med Inst, 1111 Highland Ave, Madison, WI 53705 USA
来源：
TRENDS IN NEUROSCIENCES | 2018年 / 41卷 / 06期
基金：
美国国家卫生研究院;
关键词：
NEUROTRANSMITTER RELEASE; SYNAPTIC-TRANSMISSION; PHOSPHOLIPID-BINDING; CALCIUM SENSOR; SYNAPTOTAGMIN; DOMAIN;
D O I：
10.1016/j.tins.2018.03.012
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In 1992, Brose et al. showed that the synaptic vesicle (SV) protein p65/synaptotagmin (syt) 1 binds in a mutually dependent manner Ca2+ and anionic phospholipids, prompting the idea that it functions as a Ca2+ sensor for exocytosis. These findings now define two key aspects of excitation-secretion coupling.
引用
收藏
页码：327 / 330
页数：5
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