Multicomponent 1,3-Dipolar Cycloaddition Reactions in the Construction of Hybrid Spiroheterocycles

被引：30

作者：

Arumugam, Natarajan ^{[1
]}

Kumar, Raju Suresh ^{[1
]}

Almansour, Abdulrahman I. ^{[1
]}

Perumal, Subbu ^{[2
]}

机构：

[1] King Saud Univ, Coll Sci, Dept Chem, Riyadh 11451, Saudi Arabia

[2] Madurai Kamaraj Univ, Sch Chem, Dept Organ Chem, Madurai 625021, Tamil Nadu, India

来源：

CURRENT ORGANIC CHEMISTRY | 2013年 / 17卷 / 18期

关键词：

Multicomponent; 1,3-Dipolar cycloadditions; Spiroheterocycles; Azomethine ylides and Nitrile oxides; AZOMETHINE YLIDE CYCLOADDITION; BAYLIS-HILLMAN ADDUCTS; STEREOSELECTIVE-SYNTHESIS; REGIOSELECTIVE-SYNTHESIS; ONE-POT; FACILE SYNTHESIS; DISPIRO HETEROCYCLES; BETA-LACTAMS; IONIC LIQUID; PYRROLIDINES;

D O I：

10.2174/13852728113179990091

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Spiroheterocyclic ring systems are attractive synthetic targets due to their interesting conformational features and their structural implications on their activity in biological systems. Consequently, a vast deal of research by synthetic organic as well as medicinal chemists pertains to the synthesis of these heterocycles employing diverse synthetic methodologies. Among them, one-pot multicomponent 1,3-cycloaddition reactions have emerged as preferred synthetic protocol in view of their convergence, atom economy, eco-friendliness, flexibility and facile automation. This review article focuses on the assembly of mono-, di- and multispiro heterocyclic hybrids via aforesaid synthetic methodologies with a variety of dipolarophiles.

引用

页码：1929 / 1956

页数：28

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