Polyhydroxyalkanoic acids from structurally-unrelated carbon sources in Escherichia coli

被引：33

作者：

Wang, Qian ^{[1
]}

Zhuang, Qianqian ^{[1
]}

Liang, Quanfeng ^{[1
]}

Qi, Qingsheng ^{[1
]}

机构：

[1] Shandong Univ, State Key Lab Microbial Technol, Natl Glycoengn Res Ctr, Jinan 250100, Peoples R China

来源：

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY | 2013年 / 97卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Polyhydroxyalkanoates; Unrelated carbon source; Escherichia coli; PHA; Metabolic engineering; POLY(4-HYDROXYBUTYRIC ACID); 3-HYDROXYPROPIONIC ACID; PSEUDOMONAS-AERUGINOSA; ALCALIGENES-EUTROPHUS; PHA SYNTHASE; BIOSYNTHETIC-PATHWAY; RECOMBINANT STRAINS; RALSTONIA-EUTROPHA; POLYLACTIC ACID; GLUCOSE;

D O I：

10.1007/s00253-013-4809-x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Polyhydroxyalkanoates (PHAs) that contain varied monomers with different chain lengths/structures were normally synthesized when a structurally-related precursor was present. The biosynthesis of PHAs from unrelated carbon sources in microorganisms including Escherichia coli met many challenges in the past. Recently, with the development of metabolic engineering and synthetic biology, the production of PHAs from unrelated carbon sources obtained a breakthrough. Polyesters containing 2-hydroxypropionate, 3-hydroxypropionate, 4-hydroxybutyrate, 3-hydroxyvalarate, and medium-chain-length 3-hydroxyalkanoate monomers can all be synthesized in E. coli by integrating exogenous or endogenous pathways and/or genes. This review will summarize the progresses in this area. In addition, the strategies that lead to the production of PHAs with varied monomers and high polymer content in the cell are discussed.

引用

页码：3301 / 3307

页数：7

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