99mTc-labeled oligomeric nanoparticles as potential agents for folate receptor-positive tumor targeting

被引：10
|
作者：
Liang, Lili [1 ]
Zhang, Xueqian [3 ]
Su, Xiaoyu [2 ]
Li, Jianchun [4 ]
Tian, Yong [4 ]
Xue, Hongbao [1 ]
Xu, Huiqin [2 ]
机构：
[1] Bengbu Med Coll, Dept Chem, Bengbu 233030, Anhui, Peoples R China
[2] Anhui Med Univ, Dept Nucl Med, Affiliated Hosp 1, Hefei, Anhui, Peoples R China
[3] Univ Sci & Technol China, Dept Chem, Key Lab Soft Matter Chem, Hefei, Anhui, Peoples R China
[4] Bengbu Med Coll, Fac Pharm, Bengbu, Anhui, Peoples R China
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2018年 / 61卷 / 02期
基金：
中国国家自然科学基金;
关键词：
folic acid; nanomaterial; radiolabeling; technetium (99m); FOLIC-ACID; SMALL-MOLECULE; DRUG-DELIVERY; CANCER;
D O I：
10.1002/jlcr.3577
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
One type of biocompatible nanoparticles functionalized with folate and Tc-99m was successfully synthesized. Maleimide-folic acid (Mal-FA) was selected to covalently conjugate with -SH of the nanoparticles (NPs) to prepare NPs-FA for targeting. Tc-99m was selected to conjugate with -NH2 and -SH groups of cysteine residues on the surface of NPs to prepare NPs-FA-Tc-99m for radioactive counting. The ability to target folate receptors of NPs-FA-Tc-99m was assessed in uptake studies with folate-receptor-positive human HepG2 cells. The results showed that the as-prepared NPs can selectively uptake by folate receptor-overexpressing HepG2 tumor cells in vitro. The oligomeric hybrid NPs radiolabeled with Tc-99m may develop to be SPECT/CT imaging biomaterials with high selectivity.
引用
收藏
页码：54 / 60
页数：7
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