Circulating tumor cells as a surrogate marker for determining clinical outcome to mFOLFOX chemotherapy in patients with stage III colon cancer

被引：72

作者：

Lu, C-Y ^{[1
,2
]}

Tsai, H-L ^{[3
,4
,5
]}

Uen, Y-H ^{[1
,6
,7
,8
]}

Hu, H-M

Chen, C-W ^{[9
,10
,11
]}

Cheng, T-L ^{[12
]}

Lin, S-R ^{[13
,14
]}

Wang, J-Y ^{[5
,15
,16
,17
,18
]}

机构：

[1] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Gastroenterol, Kaohsiung, Taiwan

[2] Kaohsiung Med Univ, Dept Internal Med, Fac Med, Coll Med, Kaohsiung, Taiwan

[3] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Surg, Div Gen Surg Med, Kaohsiung, Taiwan

[4] Fooyin Univ, Program Bachelor Hlth Beauty, Sch Med & Hlth Sci, Kaohsiung, Taiwan

[5] Kaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung, Taiwan

[6] Chi Mei Med Ctr, Dept Surg, Div Gen Surg, Tainan, Taiwan

[7] Chi Mei Med Ctr, Dept Med Res, Tainan, Taiwan

[8] Southern Taiwan Univ, Inst Biomed Engn, Tainan, Taiwan

[9] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Surg, Div Trauma Surg, Kaohsiung, Taiwan

[10] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Emergency Med, Kaohsiung, Taiwan

[11] Taipei Med Univ, Sch Publ Hlth & Nutr, Inst Injury Prevent & Control, Taipei, Taiwan

[12] Kaohsiung Med Univ, Coll Life Sci, Fac Biomed Sci & Environm Biol, Kaohsiung, Taiwan

[13] Fooyin Univ Hosp, Dept Med Res, Pingdong City, Pingtung County, Taiwan

[14] Fooyin Univ, Sch Med & Hlth Sci, Dept Med Technol, Kaohsiung, Taiwan

[15] Kaohsiung Med Univ, Coll Med, Inst Clin Med, Kaohsiung, Taiwan

[16] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Surg, Div Gastrointestinal & Gen Surg, Kaohsiung, Taiwan

[17] Kaohsiung Med Univ, Fac Med, Coll Med, Dept Surg, Kaohsiung, Taiwan

[18] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Ctr Canc, Kaohsiung, Taiwan

来源：

BRITISH JOURNAL OF CANCER | 2013年 / 108卷 / 04期

关键词：

colon cancer; circulating tumour cells; mFOLFOX; postoperative relapse; SERUM CARCINOEMBRYONIC ANTIGEN; METASTATIC COLORECTAL-CANCER; CURATIVE RESECTION; PROGNOSTIC-SIGNIFICANCE; MOLECULAR-DETECTION; ADJUVANT TREATMENT; PERIPHERAL-BLOOD; MEMBRANE-ARRAY; OXALIPLATIN; FLUOROURACIL;

D O I：

10.1038/bjc.2012.595

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: This study was aimed to detect post-chemotherapeutic circulating tumour cells (CTCs) in stage III colon cancer patients and identify those who were at high risk of relapse. Methods: We used human telomerase reverse transcriptase, cytokeratin-19, cytokeratin-20, and carcinoembryonic antigen (CEA) as the biomarkers to detect CTCs in 90 stage III colon cancer patients undergoing curative resection followed by mFOLFOX chemotherapy. Results: Post-chemotherapeutic relapse occurred in 30 (33.3%) patients. By univariate analysis and multivariate proportional hazards regression analysis, perineural invasion (hazard ratio (HR): 2.752; 95% confidence interval (CD: 1.026-7.381), high post-chemotherapeutic serum CEA levels (HR: 2.895; 95% Cl: 1.143-7.333) and persistent presence of post-chemotherapeutic CTCs (HR: 6.273; 95% Cl: 2.442-16.117) were independent predictors of post-chemotherapeutic relapse. In addition, the persistent presence of post-chemotherapeutic CTCs strongly correlated with reduced disease-free survival and overall survival. Accuracy of detecting relapse in post-chemotherapeutic stage Ill colon cancer patients by analysing the persistent presence of post-chemotherapeutic CTCs was higher than that by post-chemotherapeutic CEA levels (odds ratio: 50.091 vs 5.211). Conclusion: The persistent presence of post-chemotherapeutic CTCs is a potential powerful surrogate marker for determining clinical outcome in stage Ill colon cancer patients receiving adjuvant mFOLFOX chemotherapy.

引用

页码：791 / 797

页数：7

共 32 条

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