Preparation of chitosan/silk fibroin blending membrane fixed with alginate dialdehyde for wound dressing

被引：95

作者：

Gu, Zhipeng ^{[1
]}

Xie, Huixu ^{[2
]}

Huang, Chengcheng ^{[1
]}

Li, Li ^{[3
]}

Yu, Xixun ^{[1
]}

机构：

[1] Sichuan Univ, Coll Polymer Sci & Engn, Chengdu 610065, Peoples R China

[2] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610065, Peoples R China

[3] 452 Hosp Chinese PLA, Dept Oncol, Chengdu 610021, Sichuan Provinc, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2013年 / 58卷

关键词：

Chitosan; Silk; Blending membrane; Alginate dialdehyde; Wound dressing; COMPOSITE NANOFIBERS; FABRICATION; SCAFFOLD; CULTURE; FILMS;

D O I：

10.1016/j.ijbiomac.2013.03.059

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The objective of this work was to prepare chitosan/silk fibroin (CS/SF) blending membranes crosslinked with alginate dialdehyde (ADA) as wound dressings and to evaluate the physical properties and biocompatibility of the membranes. The morphology of membrane was observed by scanning electron microscopy (SEM) which showed that the well consistency of these two compositions. Further, the stability, water absorption and water vapor permeability of the ADA fixed CS/SF membranes could meet the needs of wound dressing. Furthermore, the biocompatibility of ADA fixed membranes was investigated by MTT assays and SEM in vitro, and the membranes were found to promote the cell attachment and proliferation. These results suggest that ADA fixed CS/SF blending membranes with a suitable ratio could be a promising candidate for wound healing applications. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：121 / 126

页数：6

共 19 条

[1] Applications of chitin- and chitosan-derivatives for the detoxification of water and wastewater - A short review [J].

Bhatnagar, Amit ;

Sillanpaa, Mika .

ADVANCES IN COLLOID AND INTERFACE SCIENCE, 2009, 152 (1-2) :26-38

[2] WOUND MANAGEMENT WITH N-CARBOXYBUTYL CHITOSAN [J].

BIAGINI, G ;

BERTANI, A ;

MUZZARELLI, R ;

DAMADEI, A ;

DIBENEDETTO, G ;

BELLIGOLLI, A ;

RICCOTTI, G ;

ZUCCHINI, C ;

RIZZOLI, C .

BIOMATERIALS, 1991, 12 (03) :281-286

[3] Wound healing dressings and drug delivery systems: A review [J].

Boateng, Joshua S. ;

Matthews, Kerr H. ;

Stevens, Howard N. E. ;

Eccleston, Gillian M. .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2008, 97 (08) :2892-2923

[4]

BOUCEK RJ, 1984, OTOLARYNG CLIN N AM, V17, P243

[5] Fabrication of Chitosan/Silk Fibroin Composite Nanofibers for Wound-dressing Applications [J].

Cai, Zeng-xiao ;

Mo, Xiu-mei ;

Zhang, Kui-hua ;

Fan, Lin-peng ;

Yin, An-lin ;

He, Chuang-long ;

Wang, Hong-sheng .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2010, 11 (09) :3529-3539

[6] Preparation and characterization of oxidized alginate covalently cross-linked galactosylated chitosan scaffold for liver tissue engineering [J].

Chen, Feng ;

Tian, Meng ;

Zhang, Dongming ;

Wang, Jianyun ;

Wang, Qiguang ;

Yu, Xixun ;

Zhang, Xiaohua ;

Wan, Changxiu .

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2012, 32 (02) :310-320

[7] Preparation and characterization of biomimetic silk fibroin/chitosan composite nanofibers by electrospinning for osteoblasts culture [J].

Chen, Jyh-Ping ;

Chen, Shih-Hsien ;

Lai, Guo-Jyun .

NANOSCALE RESEARCH LETTERS, 2012, 7 :1-11

[8]

Dyakonov T., 2012, J DRUG DELIVERY, V2012, P490

[9] Preparation of cross-linked biocompatible poly(2-methacryloyloxyethyl phosphorylcholine) gel and its strange swelling behavior in water/ethanol mixture [J].

Kiritoshi, Y ;

Ishihara, K .

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2002, 13 (02) :213-224

[10] Properties and Biocompatibility of Chitosan and Silk Fibroin Blend Films for Application in Skin Tissue Engineering [J].

Luangbudnark, Witoo ;

Viyoch, Jarupa ;

Laupattarakasem, Wiroon ;

Surakunprapha, Palakorn ;

Laupattarakasem, Pisamai .

SCIENTIFIC WORLD JOURNAL, 2012,

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