Molecular alterations in metaplastic breast carcinoma

被引：31

作者：

Cooper, Caroline Louise ^{[1
,2
]}

Karim, Rooshdiya Z. ^{[1
,2
]}

Selinger, Christina ^{[1
]}

Carmalt, Hugh ^{[2
,3
]}

Lee, C. Soon ^{[1
,2
,4
,5
,6
]}

O'Toole, Sandra A. ^{[1
,2
,7
,8
,9
]}

机构：

[1] Royal Prince Alfred Hosp, Dept Tissue Pathol & Diagnost Oncol, Camperdown, NSW 2050, Australia

[2] Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia

[3] Royal Prince Alfred Hosp, Dept Breast Surg, Camperdown, NSW 2050, Australia

[4] Univ Western Sydney, Sch Med, Dept Pathol, Liverpool, NSW, Australia

[5] Ingham Inst Appl Med Res, Canc Pathol & Cell Biol Lab, Sydney, NSW, Australia

[6] Univ New S Wales, South West Sydney Clin Sch, Sydney, NSW 2052, Australia

[7] St Vincents Hosp, Garvan Inst Med Res, Kinghorn Canc Ctr, Darlinghurst, NSW 2010, Australia

[8] Royal Prince Alfred Hosp, Dept Mol & Clin Genet, Camperdown, NSW 2050, Australia

[9] Univ New S Wales, St Vincents Med Sch, Sydney, NSW 2052, Australia

来源：

JOURNAL OF CLINICAL PATHOLOGY | 2013年 / 66卷 / 06期

关键词：

ALPHA-B-CRYSTALLIN; EPITHELIAL-MESENCHYMAL TRANSITION; SITU HYBRIDIZATION ANALYSIS; CADHERIN-REPRESSOR-SNAIL; OF-THE-LITERATURE; BASAL-LIKE; GENE-EXPRESSION; BETA-CATENIN; NEOADJUVANT CHEMOTHERAPY; DIFFERENTIAL EXPRESSION;

D O I：

10.1136/jclinpath-2012-201086

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Metaplastic carcinoma of the breast is a rare and heterogeneous subtype of breast carcinoma with a generally poor outcome, and few therapeutic options once disease recurs or progresses. Metaplastic carcinomas of the breast are usually of a larger size at diagnosis, with less frequent nodal metastasis compared with invasive ductal carcinoma no special type, and lack hormone and HER2 receptor expression. Recent research has revealed some potentially actionable genetic changes in a subset of these rare tumours. However, ongoing efforts to further characterise the genetic basis and the molecular alterations underlying the distinctive morphological and clinical characteristics of these tumours are needed in order to identify new targets for treatment. This review will describe the theories of pathogenesis of metaplastic breast carcinoma, and highlight genetic changes and potential therapeutic targets in this generally poor prognosis malignancy.

引用

页码：522 / 528

页数：7

共 87 条

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