[1] Heidelberg Univ, Heidelberg, Germany
[2] Univ Uppsala Hosp, Uppsala Clin Rsch Cntr, Uppsala, Sweden
[3] Univ Uppsala Hosp, Uppsala Clin Rsch Cntr, Heidelberg, Sweden
[4] Asra Zeneca Rsch, Rsch & Dev, Molndal, Sweden
[5] Aarhus Unil Hosp, Dept Biomed, Cntr Clin Pharmacol, Aarhus, Denmark
[6] Univ Alberta, Dept Med, Edmonton, AB, Canada