International Fetal Cardiac Intervention Registry A Worldwide Collaborative Description and Preliminary Outcomes

被引：105

作者：

Moon-Grady, Anita J. ^{[1
]}

Morris, Shaine A. ^{[2
]}

Belfort, Michael ^{[2
]}

Chmait, Ramen ^{[3
]}

Dangel, Joanna ^{[4
]}

Devlieger, Roland ^{[5
]}

Emery, Stephen ^{[6
]}

Frommelt, Michele ^{[7
]}

Galindo, Alberto ^{[8
]}

Gelehrter, Sarah ^{[9
]}

Gembruch, Ulrich ^{[10
]}

Grinenco, Sofia ^{[11
]}

Habli, Mounira ^{[12
]}

Herberg, Ulrike ^{[13
]}

Jaeggi, Edgar ^{[14
]}

Kilby, Mark ^{[15
]}

Kontopoulos, Eftichia ^{[16
]}

Marantz, Pablo ^{[11
]}

Miller, Owen ^{[17
]}

Otano, Lucas ^{[11
]}

Pedra, Carlos ^{[18
]}

Pedra, Simone ^{[18
]}

Pruetz, Jay ^{[19
]}

Quintero, Ruben ^{[20
]}

Ryan, Greg ^{[21
]}

Sharland, Gurleen ^{[17
]}

Simpson, John ^{[17
]}

Vlastos, Emanuel ^{[22
]}

Tworetzky, Wayne ^{[23
]}

Wilkins-Haug, Louise ^{[24
]}

Oepkes, Dick ^{[25
]}

机构：

[1] Univ Calif San Francisco, San Francisco, CA 94158 USA

[2] Baylor Coll Med, Houston, TX 77030 USA

[3] Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USA

[4] Med Univ Warsaw, Perinatal Cardiol Clin, Warsaw, Poland

[5] Katholieke Univ Leuven, Univ Hosp, Leuven, Belgium

[6] Univ Pittsburgh, Med Ctr, Magee Womens Hosp, Pittsburgh, PA USA

[7] Childrens Hosp Wisconsin, Milwaukee, WI 53201 USA

[8] Univ Complutense Madrid, Fac Med, Hosp Univ Octubre 12, Madrid, Spain

[9] Univ Michigan, CS Mott Childrens Hosp, Ann Arbor, MI 48109 USA

[10] Univ Clin Bonn, Bonn, Germany

[11] Hosp Italiano Buenos Aires, Buenos Aires, DF, Argentina

[12] Cincinnati Childrens Hosp, Cincinnati, OH USA

[13] Univ Bonn, Bonn, Germany

[14] Hosp Sick Children, Toronto, ON M5G 1X8, Canada

[15] Univ Birmingham, Birmingham, W Midlands, England

[16] Jackson Mem Hosp, Miami, FL 33136 USA

[17] Evelina London Childrens Hosp, London, England

[18] Hosp Coracao, Sao Paulo, Brazil

[19] Childrens Hosp Los Angeles, Los Angeles, CA 90027 USA

[20] Univ Miami, Miller Sch Med, Miami, FL 33136 USA

[21] Univ Toronto, Mt Sinai Hosp, Toronto, ON M5G 1X5, Canada

[22] SSM Cardinal Glennon Childrens Med Ctr, St Louis, MO USA

[23] Boston Childrens Hosp, Boston, MA USA

[24] Brigham & Womens Hosp, Boston, MA 02115 USA

[25] Leiden Univ, Med Ctr, Leiden, Netherlands

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2015年 / 66卷 / 04期

关键词：

congenital heart defects; fetal cardiac intervention; fetal echocardiography; valvuloplasty; LEFT-HEART SYNDROME; CRITICAL PULMONARY STENOSIS; TRICUSPID-VALVE SIZE; ATRIAL SEPTUM; AORTIC VALVULOPLASTY; VENTRICULAR SEPTUM; IN-UTERO; INTACT; ATRESIA; FETUS;

D O I：

10.1016/j.jacc.2015.05.037

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND Invasive fetal cardiac intervention (FCI) has been reported in single-institution series, promoting technical and physiologic success. OBJECTIVES This study describes the creation of an international registry of cases presenting for FCI, intended to compile technical and outcome data from a multicenter cohort. METHODS For this initial analysis, the entire database of the International Fetal Cardiac Intervention Registry (IFCIR) was queried for details of diagnoses, procedures, and outcomes. Maternal-fetal dyads from January 2001 through June 2014 were included. RESULTS Eighteen institutions submitted data by data harvest. Of 370 cases entered, 245 underwent FCI: 100 aortic valvuloplasties from a previous single-center report (excluded from additional reporting here), an additional 86 aortic and 16 pulmonary valvuloplasties, 37 atrial septal cases, and 6 unclassified cases. FCI did not appear to affect overall survival to hospital discharge. Among live-born infants with a fetal diagnosis of aortic stenosis/evolving hypoplastic left heart syndrome, more than twice as many were discharged with biventricular circulation after successful FCI versus those meeting institutional criteria but without any or successful FCI (42.8% vs. 19.4%, respectively). When fetal deaths were counted as treatment failures, the percentages were similar: biventricular circulation at discharge was 31.3% versus 18.5% for those discharged with univentricular palliation. Survival to discharge for live-born fetuses with atrial restriction was similar to that of those undergoing technically successful versus unsuccessful FCI (63.6% vs. 46.7%, respectively), although criteria for diagnosis were nonuniform. CONCLUSIONS We describe the contents of the IFCIR and present post-natal data to suggest potential benefit to fetal therapy among pregnancies considered for possible intervention and support proposals for additional work. (C) 2015 by the American College of Cardiology Foundation.

引用

页码：388 / 399

页数：12

共 33 条

[1] A Randomized Trial of Prenatal versus Postnatal Repair of Myelomeningocele [J].

Adzick, N. Scott ;

Thom, Elizabeth A. ;

Spong, Catherine Y. ;

Brock, John W., III ;

Burrows, Pamela K. ;

Johnson, Mark P. ;

Howell, Lori J. ;

Farrell, Jody A. ;

Dabrowiak, Mary E. ;

Sutton, Leslie N. ;

Gupta, Nalin ;

Tulipan, Noel B. ;

D'Alton, Mary E. ;

Farmer, Diana L. .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (11) :993-1004

[2] Intrauterine aortic valvuloplasty in fetuses with critical aortic stenosis: experience and results of 24 procedures [J].

Arzt, W. ;

Wertaschnigg, D. ;

Veit, I. ;

Klement, F. ;

Gitter, R. ;

Tulzer, G. .

ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2011, 37 (06) :689-695

[3] Invasive intrauterine treatment of pulmonary atresia/intact ventricular septum with heart failure [J].

Arzt, W ;

Tulzer, G ;

Aigner, M ;

Mair, R ;

Hafner, E .

ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2003, 21 (02) :186-188

[4] Fetal stenting of the atrial septum: Technique and initial results in cardiac lesions with left atrial hypertension [J].

Chaturvedi, Rajiv R. ;

Ryan, Greg ;

Seed, Michael ;

van Arsdell, Glen ;

Jaeggi, Edgar T. .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2013, 168 (03) :2029-2036

[5] Fetal Interventions for Congenital Heart Disease in Brazil [J].

Fernandes Fontes Pedra, Simone Rolim ;

Andrioli Peralta, Cleisson Fabio ;

Crema, Luciana ;

Jatene, Ieda Bosisio ;

da Costa, Rodrigo Nieckel ;

Cardoso Pedra, Carlos Augusto .

PEDIATRIC CARDIOLOGY, 2014, 35 (03) :399-405

[6] Fetal Aortic Valvuloplasty for Evolving Hypoplastic Left Heart Syndrome Postnatal Outcomes of the First 100 Patients [J].

Freud, Lindsay R. ;

McElhinney, Doff B. ;

Marshall, Audrey C. ;

Marx, Gerald R. ;

Friedman, Kevin G. ;

del Nido, Pedro J. ;

Emani, Sitaram M. ;

Lafranchi, Terra ;

Silva, Virginia ;

Wilkins-Haug, Louise E. ;

Benson, Carol B. ;

Lock, James E. ;

Tworetzky, Wayne .

CIRCULATION, 2014, 130 (08) :638-+

[7] Pulmonary balloon valvuloplasty in a fetus with critical pulmonary stenosis/atresia with intact ventricular septum and heart failure [J].

Galindo, A ;

Gutiérrez-Larraya, F ;

Velasco, JM ;

de la Fuente, P .

FETAL DIAGNOSIS AND THERAPY, 2006, 21 (01) :100-104

[8] Morphologic and functional predictors of eventual circulation in the fetus with pulmonary atresia or critical pulmonary stenosis with intact septum [J].

Gardiner, Helena M. ;

Belmar, Cristian ;

Tulzer, Gerald ;

Barlow, Anna ;

Pasquini, Lucia ;

Carvalho, Julene S. ;

Daubeney, Piers E. F. ;

Rigby, Michael L. ;

Gordon, Fabiana ;

Kulinskaya, Elena ;

Franklin, Rodney C. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2008, 51 (13) :1299-1308

[9] Maternal morbidity after maternal-fetal surgery [J].

Golombeck, K ;

Ball, RH ;

Lee, HM ;

Farrell, JA ;

Farmer, DL ;

Jacobs, VR ;

Rosen, MA ;

Filly, RA ;

Harrison, MR .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2006, 194 (03) :834-839

[10] Fetal Intervention in Right Outflow Tract Obstructive Disease: Selection of Candidates and Results [J].

Gomez Montes, E. ;

Herraiz, I. ;

Mendoza, A. ;

Galindo, A. .

CARDIOLOGY RESEARCH AND PRACTICE, 2012, 2012

← 1 2 3 4 →