FDG-PET is prognostic and predictive for progression-free survival in relapsed follicular lymphoma: exploratory analysis of the GAUSS study

被引：13

作者：

Kostakoglu, Lale ^{[1
]}

Goy, Andre ^{[2
]}

Martinelli, Giovanni ^{[3
]}

Caballero, Dolores ^{[4
]}

Crump, Michael ^{[5
]}

Gaidano, Gianluca ^{[6
]}

Baetz, Tara ^{[7
]}

Buckstein, Rena ^{[8
]}

Fine, Gregg ^{[9
]}

Fingerle-Rowson, Guenter ^{[10
]}

Berge, Claude ^{[10
]}

Sahin, Deniz ^{[10
]}

Press, Oliver ^{[11
]}

Sehn, Laurie ^{[12
]}

机构：

[1] Mt Sinai Hosp, Dept Radiol, New York, NY 10029 USA

[2] John Theurer Canc Ctr HUMC, Hackensack, NJ USA

[3] IEO Ist Europeo Oncol, Dept Haematol Oncol, Milan, Italy

[4] Univ Hosp Salamanca, Dept Hematol, Salamanca, Spain

[5] Univ Toronto, Princess Margaret Hosp, Toronto, ON, Canada

[6] Amedeo Avogadro Univ Eastern Piedmont, Div Hematol, Dept Translat Med, Novara, Italy

[7] Queens Univ, Kingston Gen Hosp, Div Med Oncol, Kingston, ON, Canada

[8] Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada

[9] Genentech Inc, San Francisco, CA 94080 USA

[10] F Hoffmann La Roche, Basel, Switzerland

[11] Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA

[12] British Columbia Canc Agcy, Ctr Lymphoid Canc, Vancouver, BC, Canada

来源：

LEUKEMIA & LYMPHOMA | 2017年 / 58卷 / 02期

关键词：

FDG PET/CT; follicular lymphoma; prediction of response; relapse; POSITRON-EMISSION-TOMOGRAPHY; B-CELL LYMPHOMA; METABOLIC TUMOR VOLUME; FONDAZIONE ITALIANA LINFOMI; NON-HODGKIN-LYMPHOMA; RESPONSE ASSESSMENT; QUANTIZATION PARAMETERS; FINAL ANALYSIS; DES LYMPHOMES; TRIAL;

D O I：

10.1080/10428194.2016.1196815

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

An exploratory analysis of 75 follicular lymphoma patients treated with obinutuzumab or rituximab induction therapy (IT) for 4 weeks in the phase II GAUSS study aimed to determine whether positron emission tomography (PET) results could predict progression-free survival (PFS) and tumor response. The proportion of patients with a PFS event (progression or death) was higher in those who were PET-positive after IT (assessed using Deauville five-point scale criteria; 35/52, 67%) than PET-negative (5/20, 25%); the hazard ratio for progression or death was 0.25 (95%CI: 0.01-0.64; p=0.0018). A significant association was also found when PET results were assessed using International Harmonization Project and European Organisation for Research and Treatment of Cancer criteria. Change between baseline and end of IT in values of standardized uptake value and other PET parameters were associated with PFS and response. Validation of these results in prospective studies of larger cohorts is warranted.

引用

页码：372 / 381

页数：10

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