The Lymphatic Vasculature in the 21st Century: Novel Functional Roles in Homeostasis and Disease

被引：471

作者：

Oliver, Guillermo ^{[1
]}

Kipnis, Jonathan ^{[2
,3
]}

Randolph, Gwendalyn J. ^{[4
]}

Harvey, Natasha L. ^{[5
,6
]}

机构：

[1] Northwestern Univ, Ctr Vasc & Dev Biol, Feinberg Cardiovasc Res Inst, Feinberg Sch Med, Chicago, IL 60611 USA

[2] Univ Virginia, Ctr Brain Immunol & Glia BIG, Charlottesville, VA 22908 USA

[3] Univ Virginia, Dept Neurosci, Charlottesville, VA 22908 USA

[4] Washington Univ, Dept Pathol & Immunol, Sch Med, St Louis, MO 63110 USA

[5] Univ South Australia, Ctr Canc Biol, Adelaide, SA, Australia

[6] SA Pathol, Adelaide, SA, Australia

来源：

CELL | 2020年 / 182卷 / 02期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

GROWTH-FACTOR-C; PRIMARY CONGENITAL GLAUCOMA; INFLAMMATORY-BOWEL-DISEASE; HIGH-DENSITY-LIPOPROTEINS; SCHLEMMS CANAL INTEGRITY; CENTRAL-NERVOUS-SYSTEM; ENDOTHELIAL-CELLS; HEREDITARY LYMPHEDEMA; TRANSCRIPTION FACTOR; CARDIAC LYMPHATICS;

D O I：

10.1016/j.cell.2020.06.039

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mammals have two specialized vascular circulatory systems: the blood vasculature and the lymphatic vasculature. The lymphatic vasculature is a unidirectional conduit that returns filtered interstitial arterial fluid and tissue metabolites to the blood circulation. It also plays major roles in immune cell trafficking and lipid absorption. As we discuss in this review, the molecular characterization of lymphatic vascular development and our understanding of this vasculature's role in pathophysiological conditions has greatly improved in recent years, changing conventional views about the roles of the lymphatic vasculature in health and disease. Morphological or functional defects in the lymphatic vasculature have now been uncovered in several pathological conditions. We propose that subtle asymptomatic alterations in lymphatic vascular function could underlie the variability seen in the body's response to a wide range of human diseases.

引用

页码：270 / 296

页数：27

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