The impact of orbitofrontal dysfunction on cocaine addiction

被引：153

作者：

Lucantonio, Federica ^{[1
]}

Stalnaker, Thomas A. ^{[2
]}

Shaham, Yavin ^{[2
]}

Niv, Yael ^{[3
,4
]}

Schoenbaum, Geoffrey ^{[1
,2
]}

机构：

[1] Univ Maryland, Sch Med, Dept Anat & Neurobiol, Baltimore, MD 21201 USA

[2] Natl Inst Drug Abuse, Intramural Res Program, Baltimore, MD USA

[3] Princeton Univ, Dept Psychol, Princeton, NJ 08544 USA

[4] Princeton Univ, Inst Neurosci, Princeton, NJ 08544 USA

来源：

NATURE NEUROSCIENCE | 2012年 / 15卷 / 03期

关键词：

ORBITAL PREFRONTAL CORTEX; DECISION-MAKING; DRUG-ADDICTION; BASOLATERAL AMYGDALA; NEURONAL-ACTIVITY; METHAMPHETAMINE ABUSERS; AMPHETAMINE EXPOSURE; BEHAVIORAL-CONTROL; REWARD PREFERENCE; EXPERIENCED RATS;

D O I：

10.1038/nn.3014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cocaine addiction is characterized by poor judgment and maladaptive decision-making. Here we review evidence implicating the orbitofrontal cortex in such behavior. This evidence suggests that cocaine-induced changes in orbitofrontal cortex disrupt the representation of states and transition functions that form the basis of flexible and adaptive 'model-based' behavioral control. By impairing this function, cocaine exposure leads to an overemphasis on less flexible, maladaptive 'model-free' control systems. We propose that such an effect accounts for the complex pattern of maladaptive behaviors associated with cocaine addiction.

引用

页码：358 / 366

页数：9

共 100 条

[41] Plasticity and functions of the orbital frontal cortex [J].

Kolb, B ;

Pellis, S ;

Robinson, TE .

BRAIN AND COGNITION, 2004, 55 (01) :104-115

[42] RESCORLA-WAGNER MODEL - LOSSES IN ASSOCIATIVE STRENGTH IN COMPOUND CONDITIONED STIMULI [J].

KREMER, EF .

JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIOR PROCESSES, 1978, 4 (01) :22-36

[43] Prior chronic cocaine exposure in mice induces persistent alterations in cognitive function [J].

Krueger, Dilja D. ;

Howell, Jessica L. ;

Oo, Heyman ;

Olausson, Peter ;

Taylor, Jane R. ;

Nairn, Angus C. .

BEHAVIOURAL PHARMACOLOGY, 2009, 20 (08) :695-704

[44] Involvement of the lateral orbitofrontal cortex in drug context-induced reinstatement of cocaine-seeking behavior in rats [J].

Lasseter, Heather C. ;

Ramirez, Donna R. ;

Xie, Xiaohu ;

Fuchs, Rita A. .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2009, 30 (07) :1370-1381

[45] Functional dissociation in frontal and striatal areas for processing of positive and negative reward information [J].

Liu, Xun ;

Powell, David K. ;

Wang, Hongbin ;

Gold, Brian T. ;

Corbly, Christine R. ;

Joseph, Jane E. .

JOURNAL OF NEUROSCIENCE, 2007, 27 (17) :4587-4597

[46]

LONDON ED, 1990, ARCH GEN PSYCHIAT, V47, P567

[47] Central amygdala ERK signaling pathway is critical to incubation of cocaine craving [J].

Lu, L ;

Hope, BT ;

Dempsey, J ;

Liu, SY ;

Bossert, JM ;

Shaham, Y .

NATURE NEUROSCIENCE, 2005, 8 (02) :212-219

[48] White matter hyperintensities in subjects with cocaine and opiate dependence and healthy comparison subjects [J].

Lyoo, IK ;

Streeter, CC ;

Ahn, KH ;

Lee, HK ;

Pollack, MH ;

Silveri, MM ;

Nassar, L ;

Levin, JM ;

Sarid-Segal, O ;

Ciraulo, DA ;

Renshaw, PF ;

Kaufman, MJ .

PSYCHIATRY RESEARCH-NEUROIMAGING, 2004, 131 (02) :135-145

[49] Ventral Striatum and Orbitofrontal Cortex Are Both Required for Model-Based, But Not Model-Free, Reinforcement Learning [J].

McDannald, Michael A. ;

Lucantonio, Federica ;

Burke, Kathryn A. ;

Niv, Yael ;

Schoenbaum, Geoffrey .

JOURNAL OF NEUROSCIENCE, 2011, 31 (07) :2700-2705

[50] Drug therapy: Management of cocaine abuse and dependence [J].

Mendelson, JH ;

Mello, NK .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (15) :965-972

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