The impact of orbitofrontal dysfunction on cocaine addiction

被引：153

作者：

Lucantonio, Federica ^{[1
]}

Stalnaker, Thomas A. ^{[2
]}

Shaham, Yavin ^{[2
]}

Niv, Yael ^{[3
,4
]}

Schoenbaum, Geoffrey ^{[1
,2
]}

机构：

[1] Univ Maryland, Sch Med, Dept Anat & Neurobiol, Baltimore, MD 21201 USA

[2] Natl Inst Drug Abuse, Intramural Res Program, Baltimore, MD USA

[3] Princeton Univ, Dept Psychol, Princeton, NJ 08544 USA

[4] Princeton Univ, Inst Neurosci, Princeton, NJ 08544 USA

来源：

NATURE NEUROSCIENCE | 2012年 / 15卷 / 03期

关键词：

ORBITAL PREFRONTAL CORTEX; DECISION-MAKING; DRUG-ADDICTION; BASOLATERAL AMYGDALA; NEURONAL-ACTIVITY; METHAMPHETAMINE ABUSERS; AMPHETAMINE EXPOSURE; BEHAVIORAL-CONTROL; REWARD PREFERENCE; EXPERIENCED RATS;

D O I：

10.1038/nn.3014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cocaine addiction is characterized by poor judgment and maladaptive decision-making. Here we review evidence implicating the orbitofrontal cortex in such behavior. This evidence suggests that cocaine-induced changes in orbitofrontal cortex disrupt the representation of states and transition functions that form the basis of flexible and adaptive 'model-based' behavioral control. By impairing this function, cocaine exposure leads to an overemphasis on less flexible, maladaptive 'model-free' control systems. We propose that such an effect accounts for the complex pattern of maladaptive behaviors associated with cocaine addiction.

引用

页码：358 / 366

页数：9

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