Asian perspectives on the recognition and management of levodopa 'wearing-off' in Parkinson's disease

被引：22

作者：

Bhidayasiri, Roongroj ^{[1
,2
]}

Hattori, Nobutaka ^{[3
]}

Jeon, Beomseok ^{[4
]}

Chen, Rou-Shayn ^{[5
]}

Lee, Moon Keen ^{[6
]}

Bajwa, Jawad A. ^{[7
]}

Mok, Vincent C. T. ^{[8
]}

Zhang, Baorong ^{[9
]}

Syamsudin, Thamrin ^{[10
]}

Tan, Louis Chew Seng ^{[11
]}

Jamora, Roland Dominic G. ^{[12
,13
,14
]}

Pisarnpong, Apichart ^{[15
]}

Poewe, Werner ^{[16
]}

机构：

[1] Chulalongkorn Univ, Fac Med, Chulalongkorn Ctr Excellence Parkinsons Dis & Rel, Bangkok 10330, Thailand

[2] King Chulalongkorn Mem Hosp, Thai Red Cross Soc, Bangkok, Thailand

[3] Juntendo Univ, Sch Med, Tokyo 113, Japan

[4] Seoul Natl Univ, Seoul, South Korea

[5] Chang Gung Mem Hosp, Lingkou, Taiwan

[6] Sunway Med Ctr, Petaling Jaya 46150, Selangor, Malaysia

[7] Natl Inst Neurosci, Riyadh, Saudi Arabia

[8] Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China

[9] Zhejiang Univ, Sch Med, Dept Neurol, Affiliated Hosp 2, Hangzhou 310003, Zhejiang, Peoples R China

[10] Natl Brain Ctr Hosp, Jakarta, Indonesia

[11] Natl Inst Neurosci, Singapore, Singapore

[12] Univ Philippines Manila, Dept Neurosci, Coll Med, Philippine Gen Hosp, Manila, Philippines

[13] St Lukes Med Ctr Quezon City & Global City, Movement Disorder Serv, Inst Neurosci, Quezon City, Philippines

[14] St Lukes Med Ctr Quezon City & Global City, Neurol Sect, Inst Neurosci, Quezon City, Philippines

[15] Bangkok Hosp, Dept Neurol, Bangkok, Thailand

[16] Med Univ Innsbruck, A-6020 Innsbruck, Austria

来源：

EXPERT REVIEW OF NEUROTHERAPEUTICS | 2015年 / 15卷 / 11期

关键词：

Arab; Asia; fluctuations; non-motor; Parkinson's disease; screening tools; wearing-off; CATECHOL-O-METHYLTRANSFERASE; DEEP BRAIN-STIMULATION; ROPINIROLE PROLONGED RELEASE; CARBIDOPA INTESTINAL GEL; PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; MOTOR COMPLICATIONS; NONMOTOR FLUCTUATIONS; SUBCUTANEOUS APOMORPHINE; VAL158MET POLYMORPHISM;

D O I：

10.1586/14737175.2015.1088783

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Most Parkinson's disease patients will receive levodopa therapy, and of these, the majority will develop some levodopa-induced complications. For many patients, the first complication to develop is the decline in the duration of therapeutic benefit of each levodopa dose, a phenomenon commonly termed wearing-off'. There is already extensive literature documenting the epidemiology and management of wearing-off in Parkinson's disease patients of western descent. However, data derived from these studies might not always apply to patients of Asian descent due to genetic variations, differences in co-morbidities or non-availability of certain drugs. This review summarizes the current literature regarding the epidemiology of wearing-off in Asian (including Arab) patients and discusses the management issues in the context of drug availability in Asia.

引用

页码：1285 / 1297

页数：13

共 99 条

[1] Frequency of levodopa-related dyskinesias and motor fluctuations as estimated from the cumulative literature [J].