microRNAs regulate adipocyte differentiation

被引：58

作者：

Chen, Lin ^{[1
,2
]}

Song, Jinlin ^{[3
]}

Cui, Junhui ^{[2
]}

Hou, Jia ^{[1
]}

Zheng, Xiaohui ^{[2
]}

Li, Cai ^{[1
]}

Liu, Lei ^{[2
]}

机构：

[1] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610044, Peoples R China

[2] Sichuan Univ, West China Hosp Stomatol, Dept Oral & Maxillofacial Surg, Chengdu 610041, Peoples R China

[3] Chongqing Med Univ, Affiliated Hosp Stomatol, Chongqing 401147, Peoples R China

来源：

CELL BIOLOGY INTERNATIONAL | 2013年 / 37卷 / 06期

基金：

高等学校博士学科点专项科研基金;

关键词：

adipocyte; adipogenesis; microRNAs; regulation; MITOTIC CLONAL EXPANSION; MESENCHYMAL STEM-CELLS; BINDING-PROTEIN-ALPHA; ADIPOGENIC DIFFERENTIATION; ADIPOSE-TISSUE; PPAR-GAMMA; C/EBP-ALPHA; PREADIPOCYTE DIFFERENTIATION; DEVELOPMENTAL ORIGIN; NEGATIVE REGULATOR;

D O I：

10.1002/cbin.10063

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The number of adipocytes is relevant to the extent of differentiation from pluripotent stem cells into pre-adipocytes, whereas the size of adipocytes relates to the extent of differentiation from pre-adipocytes into mature fat cells and the accumulation of triglyceride. Investigation of the molecular regulatory mechanism of adipocyte differentiation is not only essential for understanding the physiological processes of adipogenesis, but it is also important for identifying new biomarkers and therapeutic targets for some metabolic diseases, such as obesity and diabetes. microRNAs (miRNAs) appear to play important roles in adipocyte differentiation. During adipogenesis, miRNAs can accelerate or inhibit adipocyte differentiation by acting on transcription factors, regulating signalling pathways related to adipogenesis, or blocking the mitotic clonal expansion stage, thus regulating adipocyte development. The regulatory role of some miRNAs varies in different species or different cells. In this review, the biological characteristics of miRNA and the adipocyte differentiation process are concisely discussed. Recent advances in our understanding of the role of miRNAs in adipocytes development or adipogenesis are discussed.

引用

页码：533 / 546

页数：14

共 127 条

[21] miR-148 targets human DNMT3b protein coding region [J].

Duursma, Anja M. ;

Kedde, Martijn ;

Schrier, Mariette ;

Le Sage, Carlos ;

Agami, Reuven .

RNA, 2008, 14 (05) :872-877

[22] The regulation of E2F by pRB-family proteins [J].

Dyson, N .

GENES & DEVELOPMENT, 1998, 12 (15) :2245-2262

[23] miR-375 targets 3'-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic β-cells [J].

El Ouaamari, Abdelfattah ;

Baroukh, Nadine ;

Martens, Geert A. ;

Lebrun, Patricia ;

Pipeleers, Daniel ;

van Obberghen, Emmanuel .

DIABETES, 2008, 57 (10) :2708-2717

[24] The Origins of Brown Adipose Tissue. [J].

Enerbaeck, Sven .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (19) :2021-2023

[25] MicroRNA-143 regulates adipocyte differentiation [J].

Esau, C ;

Kang, XL ;

Peralta, E ;

Hanson, E ;

Marcusson, EG ;

Ravichandran, LV ;

Sun, YQ ;

Koo, S ;

Perera, RJ ;

Jain, R ;

Dean, NM ;

Freier, SM ;

Bennett, CF ;

Lollo, B ;

Griffey, R .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (50) :52361-52365

[26] GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay [J].

Eulalio, Ana ;

Huntzinger, Eric ;

Izaurralde, Elisa .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2008, 15 (04) :346-353

[27] E2Fs regulate adipocyte differentiation [J].

Fajas, L ;

Landsberg, RL ;

Huss-Garcia, Y ;

Sardet, C ;

Lees, JA ;

Auwerx, J .

DEVELOPMENTAL CELL, 2002, 3 (01) :39-49

[28] Transcriptional control of adipocyte formation [J].

Farmer, Stephen R. .

CELL METABOLISM, 2006, 4 (04) :263-273

[29] Adipogenesis:: cellular and molecular aspects [J].

Fève, B .

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 19 (04) :483-499

[30]

Frey RS, 1997, CANCER RES, V57, P628

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