microRNAs regulate adipocyte differentiation

被引:58
作者
Chen, Lin [1 ,2 ]
Song, Jinlin [3 ]
Cui, Junhui [2 ]
Hou, Jia [1 ]
Zheng, Xiaohui [2 ]
Li, Cai [1 ]
Liu, Lei [2 ]
机构
[1] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610044, Peoples R China
[2] Sichuan Univ, West China Hosp Stomatol, Dept Oral & Maxillofacial Surg, Chengdu 610041, Peoples R China
[3] Chongqing Med Univ, Affiliated Hosp Stomatol, Chongqing 401147, Peoples R China
基金
高等学校博士学科点专项科研基金;
关键词
adipocyte; adipogenesis; microRNAs; regulation; MITOTIC CLONAL EXPANSION; MESENCHYMAL STEM-CELLS; BINDING-PROTEIN-ALPHA; ADIPOGENIC DIFFERENTIATION; ADIPOSE-TISSUE; PPAR-GAMMA; C/EBP-ALPHA; PREADIPOCYTE DIFFERENTIATION; DEVELOPMENTAL ORIGIN; NEGATIVE REGULATOR;
D O I
10.1002/cbin.10063
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The number of adipocytes is relevant to the extent of differentiation from pluripotent stem cells into pre-adipocytes, whereas the size of adipocytes relates to the extent of differentiation from pre-adipocytes into mature fat cells and the accumulation of triglyceride. Investigation of the molecular regulatory mechanism of adipocyte differentiation is not only essential for understanding the physiological processes of adipogenesis, but it is also important for identifying new biomarkers and therapeutic targets for some metabolic diseases, such as obesity and diabetes. microRNAs (miRNAs) appear to play important roles in adipocyte differentiation. During adipogenesis, miRNAs can accelerate or inhibit adipocyte differentiation by acting on transcription factors, regulating signalling pathways related to adipogenesis, or blocking the mitotic clonal expansion stage, thus regulating adipocyte development. The regulatory role of some miRNAs varies in different species or different cells. In this review, the biological characteristics of miRNA and the adipocyte differentiation process are concisely discussed. Recent advances in our understanding of the role of miRNAs in adipocytes development or adipogenesis are discussed.
引用
收藏
页码:533 / 546
页数:14
相关论文
共 127 条
[1]   MicroRNAs and other tiny endogenous RNAs in C-elegans [J].
Ambros, V ;
Lee, RC ;
Lavanway, A ;
Williams, PT ;
Jewell, D .
CURRENT BIOLOGY, 2003, 13 (10) :807-818
[2]   In vivo modulation of Hmgic reduces obesity [J].
Anand, A ;
Chada, K .
NATURE GENETICS, 2000, 24 (04) :377-380
[3]   Routes of FA delivery to cardiac muscle: modulation of lipoprotein lipolysis alters uptake of TG-derived FA [J].
Augustus, AS ;
Kako, Y ;
Yagyu, H ;
Goldberg, IJ .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2003, 284 (02) :E331-E339
[4]   MicroRNAs: Target Recognition and Regulatory Functions [J].
Bartel, David P. .
CELL, 2009, 136 (02) :215-233
[5]   MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].
Bartel, David P. .
CELL, 2007, 131 (04) :11-29
[6]   PKBα is required for adipose differentiation of mouse embryonic fibroblasts [J].
Baudry, A ;
Yang, ZZ ;
Hemmings, BA .
JOURNAL OF CELL SCIENCE, 2006, 119 (05) :889-897
[7]   Developmental origin of adipocytes: new insights into a pending question [J].
Billon, Nathalie ;
Monteiro, Miguel Caetano ;
Dani, Christian .
BIOLOGY OF THE CELL, 2008, 100 (10) :563-575
[8]   The generation of adipocytes by the neural crest [J].
Billon, Nathalie ;
Iannarelli, Palma ;
Monteiro, Miguel Caetano ;
Glavieux-Pardanaud, Corinne ;
Richardson, William D. ;
Kessaris, Nicoletta ;
Dani, Christian ;
Dupin, Elisabeth .
DEVELOPMENT, 2007, 134 (12) :2283-2292
[9]   The role of MAPKs in adipocyte differentiation and obesity [J].
Bost, F ;
Aouadi, M ;
Caron, L ;
Binétruy, B .
BIOCHIMIE, 2005, 87 (01) :51-56
[10]  
Cai Yimei, 2009, Genomics Proteomics & Bioinformatics, V7, P147, DOI 10.1016/S1672-0229(08)60044-3