Bioengineering of Metal-organic Frameworks for Nanomedicine

被引：122
作者：
Liu, Yuan [1 ]
Zhao, Yanli [2 ]
Chen, Xiaoyuan [1 ]
机构：
[1] Natl Inst Biomed Imaging & Bioengn, Lab Mol Imaging & Nanomed, NIH, Bethesda, MD 20892 USA
[2] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore
来源：
THERANOSTICS | 2019年 / 9卷 / 11期
基金：
美国国家卫生研究院;
关键词：
Metal-organic frameworks; drug delivery; photodynamic therapy; surface engineering; EFFECTIVE PHOTODYNAMIC THERAPY; DRUG-DELIVERY SYSTEM; ONE-POT SYNTHESIS; INORGANIC NANOPARTICLES; SURFACE MODIFICATION; POLYMERIC MICELLES; MOF NANOPARTICLES; RADIATION-THERAPY; POOLED SIRNAS; DNA APTAMERS;
D O I：
10.7150/thno.31918
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Controlled structure, tunable porosity, and readily chemical functionalizability make metal-organic frameworks (MOFs) a powerful biomedical tool. Nanoscale MOF particles have been increasingly studied as drug carriers, bioimaging agents, and therapeutic agents due to their excellent physiochemical properties. In this review, we start with MOF as a nanocarrier for drug delivery, covering therapeutic MOF agents followed by a comprehensive discussion of surface bioengineering of MOF for improved biostability, biocompatibility, and targeted delivery. Finally, we detail the challenges and prospects of the future of MOF research for biomedical applications.
引用
收藏
页码：3122 / 3133
页数：12
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