IL-36 RECEPTOR ANTAGONIST WITH SPECIAL EMPHASIS ON IL-38

被引：20

作者：

Shaik, Y. ^{[1
]}

Sabatino, G. ^{[2
]}

Maccauro, G. ^{[3
]}

Varvara, G. ^{[4
]}

Murmura, G. ^{[4
]}

Saggini, A. ^{[5
]}

Rosati, M. ^{[6
]}

Conti, F. ^{[6
]}

Cianchetti, E. ^{[7
]}

Caraffa, A. ^{[8
]}

Antinolfi, P. ^{[8
]}

Pandolfi, F. ^{[9
]}

Potalivo, G. ^{[8
]}

Galzio, R. ^{[10
]}

Conti, P. ^{[11
]}

Theoharides, T. C. ^{[12
]}

机构：

[1] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA

[2] Univ G dAnnunzio, Div Neonatol, Chieti, Italy

[3] Univ Cattolica Sacro Cuore, Dept Orthoped, Rome, Italy

[4] Univ G dAnnunzio, Sch Dent, Chieti, Italy

[5] Univ Roma Tor Vergata, Dept Dermatol, Rome, Italy

[6] Osped Pescara, Gynecol Div, Pescara, Italy

[7] Univ G dAnnunzio, Ortona Hosp, Chieti, Italy

[8] Univ Perugia, Orthopead Div, I-06100 Perugia, Italy

[9] Univ Cattolica Sacro Cuore, Dept Internal Med, I-00168 Rome, Italy

[10] Univ Aquila, Dept Hlth Sci, I-67100 Laquila, Italy

[11] Univ G dAnnunzio, Dept Expt & Clin Sci, Div Immunol, Chieti, Italy

[12] Tufts Univ, Sch Med, Tufts New England Med Ctr, Dept Pharmacol & Expt Therapeut Biochem & Interna, Boston, MA 02111 USA

来源：

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY | 2013年 / 26卷 / 01期

关键词：

IL-36; IL-38; cytokines; inflammation; immunity; NF-KAPPA-B; IN-VITRO; GENE-EXPRESSION; GROWTH-FACTOR; MAST-CELLS; MATRIX METALLOPROTEINASES; BIOACTIVE COMPOUND; PERIPHERAL-BLOOD; T-CELLS; ALPHA;

D O I：

10.1177/039463201302600103

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IL-36 is another family member of IL-1 and induces the production of proinflammatory cytokines and activates MAPK and NF kappa B pathways. IL-36 is a common mediator of innate and adaptive immune response and is inhibited by IL-36 receptor antagonist (RA). IL-36RA acts on IL-36 receptor ligand which exerts proinflammatory effect in vivo and in vitro. IL-38 binds to IL-36 receptor as does IL-36RA and has similar biological effects on immune cells. IL-38 is also a member of IL-1 cytokine and shares some characteristics of IL-1RA, binding the same IL-1 receptor type I. IL-38 plays a role in the pathogenesis of inflammatory diseases, exerting protective effect in some autoimmune diseases. Both IL-38 and IL-36RA have an anti-inflammatory biological effect, however in some cases have contrary effects.

引用

页码：27 / 36

页数：10

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