In vitro Studies of Functionalized Mesoporous Silica Nanoparticles for Photodynamic Therapy

被引：185
|
作者：
Tu, Hsiung-Lin [1 ]
Lin, Yu-Shen [1 ]
Lin, Hsia-Yu [2 ]
Hung, Yann [1 ]
Lo, Leu-Wei [3 ]
Chen, Yang-Fang [2 ]
Mou, Chung-Yuan [1 ]
机构：
[1] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan
[2] Natl Taiwan Univ, Dept Phys, Taipei 106, Taiwan
[3] Natl Hlth Res Inst, Div Med Engn Res, Zhunan 350, Taiwan
来源：
ADVANCED MATERIALS | 2009年 / 21卷 / 02期
关键词：
PHOTOSENSITIZING ANTICANCER DRUGS; SINGLET OXYGEN; POLYMERIC MICELLES; CARRIER SYSTEM; CELL-DEATH; DELIVERY; SOLVENTS; TUMORS;
D O I：
10.1002/adma.200800548
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A versatile platform for photodynamic therapy (PDT), mesoporous silica nanoparticles functionalized with protoporphyrin IX (PpIX-MSNs), has been developed. In vitro studies on HeLa cells show high uptake efficiency. Phototoxicity results give both irradiation time- and dosage-dependent cell death events. Because of the ease of incorporating other biomedical functional groups, we believe MSNs would be an ideal platform for biomedical applications.
引用
收藏
页码：172 / +
页数：7
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