News and Views: At Long Last, an Animal Model of Graves' Orbitopathy

被引：10
作者：
Bahn, Rebecca S. [1 ]
机构：
[1] Mayo Clin, Div Endocrinol Metab & Diabet, Rochester, MN 55905 USA
来源：
ENDOCRINOLOGY | 2013年 / 154卷 / 09期
关键词：
DISEASE; OPHTHALMOPATHY; AUTOANTIBODIES; PATHOGENESIS; EXPRESSION; PATHWAY; TSHR;
D O I：
10.1210/en.2013-1705
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
[No abstract available]
引用
收藏
页码：2989 / 2991
页数：3
相关论文
共 19 条
[1]   MECHANISMS OF DISEASE Graves' Ophthalmopathy [J].
Bahn, Rebecca S. .
NEW ENGLAND JOURNAL OF MEDICINE, 2010, 362 (08) :726-738
[2]   Reevaluating thyrotropin receptor-induced mouse models of Graves' disease and ophthalmopathy [J].
Baker, G ;
Mazziotti, G ;
von Ruhland, C ;
Ludgate, M .
ENDOCRINOLOGY, 2005, 146 (02) :835-844
[3]   Thyroid-stimulating autoantibodies in Graves disease preferentially recognize the free A subunit, not the thyrotropin holoreceptor [J].
Chazenbalk, GD ;
Pichurin, P ;
Chen, CR ;
Latrofa, F ;
Johnstone, AP ;
McLachlan, SM ;
Rapoport, B .
JOURNAL OF CLINICAL INVESTIGATION, 2002, 110 (02) :209-217
[4]   The thyrotropin receptor autoantigen in Graves disease is the culprit as well as the victim [J].
Chen, CR ;
Pichurin, P ;
Nagayama, Y ;
Latrofa, F ;
Rapoport, B ;
McLachlan, SM .
JOURNAL OF CLINICAL INVESTIGATION, 2003, 111 (12) :1897-1904
[5]   Thyrotropin receptor autoantibodies are independent risk factors for graves' ophthalmopathy and help to predict severity and outcome of the disease [J].
Eckstein, Anja K. ;
Plicht, Marco ;
Lax, Hildegard ;
Neuhaeuser, Markus ;
Mann, Klaus ;
Lederbogen, Sebastian ;
Heckmann, Christian ;
Esser, Joachim ;
Morgenthaler, Nils G. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (09) :3464-3470
[6]   Examination of Orbital Tissues in Murine Models of Graves' Disease Reveals Expression of UCP-1 and the TSHR in Retrobulbar Adipose Tissues [J].
Johnson, K. T. M. ;
Wiesweg, B. ;
Schott, M. ;
Ehlers, M. ;
Mueller, M. ;
Minich, W. B. ;
Nagayama, Y. ;
Gulbins, E. ;
Eckstein, A. K. ;
Berchner-Pfannschmidt, U. .
HORMONE AND METABOLIC RESEARCH, 2013, 45 (06) :401-407
[7]   Graves' ophthalmopathy in the absence of elevated free thyroxine and triiodothyronine levels: Prevalence, natural history, and thyrotropin receptor antibody levels [J].
Khoo, DH ;
Eng, PH ;
Ho, SC ;
Tai, ES ;
Morgenthaler, NG ;
Seah, LL ;
Fong, KS ;
Chee, SP ;
Choo, CT ;
Aw, SE .
THYROID, 2000, 10 (12) :1093-1100
[8]   A stimulatory TSH receptor antibody enhances adipogenesis via phosphoinositide 3-kinase activation in orbital preadipocytes from patients with Graves' ophthalmopathy [J].
Kumar, Seema ;
Nadeem, Sarah ;
Stan, Marius N. ;
Coenen, Michael ;
Bahn, Rebecca S. .
JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2011, 46 (03) :155-163
[9]   Animal models of Graves' disease [J].
Ludgate, M .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2000, 142 (01) :1-8
[10]   A Novel Thyroid Stimulating Immunoglobulin Bioassay Is a Functional Indicator of Activity and Severity of Graves' Orbitopathy [J].
Lytton, S. D. ;
Ponto, K. A. ;
Kanitz, M. ;
Matheis, N. ;
Kohn, L. D. ;
Kahaly, G. J. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2010, 95 (05) :2123-2131
12