Synthesis and H+/K+-ATPase Inhibitory Activity of 2-phenyl-6,7-dihydrobenzofuran-4(5H)-one Oxime Ether Derivatives

被引：1

作者：

Fang, Hubiao ^{[1
]}

Jin, Lei ^{[1
]}

Zai, Weichen ^{[1
]}

Song, Yurong ^{[1
]}

Wang, Junzhi ^{[1
]}

Huang, Nianyu ^{[1
]}

机构：

[1] China Three Gorges Univ, Coll Chem & Life Sci, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Hubei, Peoples R China

来源：

ADVANCES IN CHEMICAL, MATERIAL AND METALLURGICAL ENGINEERING, PTS 1-5 | 2013年 / 634-638卷

关键词：

2-phenyl-6,7-dihydrobenzofuran-4(5H)-one; oxime ether; H+/K+-ATPase inhibitory activity; synthesis; structure elucidation; ACID;

D O I：

10.4028/www.scientific.net/AMR.634-638.1192

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Three pairs of 2-phenyl-6,7-dihydrobenzofuran-4(5H)-one oxime and corresponding oxime ether isomers were synthesized and separated as potential anti-ulcer agent. Their structures were characterized by NMR, IR, ESI-MS and elemental analysis. Preliminarily H+/K+-ATPase activity evaluation indicated that all the target compounds had a better inhibitory effect than the commercial omeprazole with the IC50 of 2.0 similar to 30.0 mu M.

引用

页码：1192 / 1195

页数：4

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