Lack of association between PICALM rs3851179 polymorphism and Alzheimer's disease in Chinese population and APOEε4-negative subgroup

被引：24

作者：

Liu, Guiyou ^{[1
,2
]}

Zhang, Liangcai ^{[3
]}

Feng, Rennan ^{[4
]}

Liao, Mingzhi ^{[3
]}

Jiang, Yongshuai ^{[3
]}

Chen, Zugen ^{[5
]}

Zhao, Bin ^{[1
]}

Li, Keshen ^{[1
]}

机构：

[1] Guangdong Med Coll, Inst Neurol, Zhanjiang, Guangdong, Peoples R China

[2] Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Genome Anal Lab, Tianjin 300308, Peoples R China

[3] Harbin Med Univ, Coll Bioinformat Sci & Technol, Harbin, Peoples R China

[4] Harbin Med Univ, Sch Publ Hlth, Dept Food Hyg & Nutr, Harbin, Peoples R China

[5] Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA USA

来源：

NEUROBIOLOGY OF AGING | 2013年 / 34卷 / 04期

关键词：

Alzheimer's disease; Genome-wide association studies; PICALM gene; Chinese population; European ancestry; GENETIC ASSOCIATION; VARIANTS; CR-1; LOCI; CLU;

D O I：

10.1016/j.neurobiolaging.2012.08.015

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Recently, the association between PICALM rs3851179 polymorphism and Alzheimer's disease (AD) was investigated in the Chinese population by 3 independent studies. However, both allele and genotype tests failed to reveal any association. The association was identified only in the APOE epsilon 4-negative subgroup. We think that the failure to replicate the association may be because of the relatively small sample size. In this research, we reinvestigated the association using all the samples from these 3 studies (n = 2486, and 1202 cases and 1284 control subjects). We failed to replicate this association between the rs3851179 polymorphism and AD in all samples and the APOE epsilon 4-negative subgroup. Our results indicate that rs3851179 may not be an AD susceptibility locus in the Chinese population and the APOE epsilon 4-negative subgroup. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：1310.e9 / 1310.e10

页数：2

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